Assessment of urinary protein 1 and transferrin as early markers of cadmium nephrotoxicity.

Assessment of urinary protein 1 and transferrin as early markers of cadmium nephrotoxicity. Research Abstract Details 

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Assessment of urinary protein 1 and transferrin as early markers of cadmium nephrotoxicity. Abstract Text:

Transferrin and protein 1, a sex linked alpha 2-microprotein, were assayed in urine from 58 workers exposed to cadmium (Cd) in a non-ferrous smelter and from 58 age matched referents. These two new markers of nephrotoxicity were compared with urinary beta 2-microglobulin (beta 2-m), retinol binding protein (RBP), albumin, and beta-N-acetyl-glucosaminidase (NAG). The response of protein 1 to Cd tubulotoxicity was similar to that of beta 2-m, RBP, and NAG. In Cd workers, protein 1 had a correlation with urinary Cd (r = 0.56) similar to beta 2-m (r = 0.48), RBP (r = 0.58), and NAG (r = 0.49). Values of these three low molecular weight proteins and of NAG were increased only in workers with urinary Cd higher than 10 micrograms/g creatinine. Urinary transferrin and albumin were similarly affected by exposure to Cd. Their response, however, was clearly more sensitive than that of low molecular weight proteins. Prevalences of positive values of these two high molecular weight proteins were not only higher but also tended to rise at lower concentrations of Cd in urine or blood. This finding suggests that in some subjects subtle defects in glomerular barrier function may precede the onset of proximal tubular impairment after chronic exposure to Cd. It remains to be assessed whether these subjects are more at risk of developing renal insufficiency.

Assessment of urinary protein 1 and transferrin as early markers of cadmium nephrotoxicity. Publishing Authors By Initials

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Assessment of urinary protein 1 and transferrin as early markers of cadmium nephrotoxicity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: British journal of industrial medicine

VOLUME: 47

Page Numbers: 559-65

Journal Abbreviation: Br J Ind Med

ISSN: 0007-1072

DAY: 28

MONTH: Aug

YEAR: 1990

Assessment of urinary protein 1 and transferrin as early markers of cadmium nephrotoxicity. Information

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LANGUAGE: eng

NlmUniqueID: 370637

Assessment of urinary protein 1 and transferrin as early markers of cadmium nephrotoxicity. Keywords Mesh Terms:

KEYWORDS: beta 2-Microglobulin

MESH TERMS: urine

Chemical & Substance for Abstract: Assessment of urinary protein 1 and transferrin as early markers of cadmium nephrotoxicity. Information

Substance Name: Acetylglucosaminidase

Registry Number: EC 3.2.1.52

Grant and Affiliation Information for Assessment of urinary protein 1 and transferrin as early markers of cadmium nephrotoxicity.

AFFILIATION: Unit of Industrial Toxicology and Occupational Medicine, Catholic University of Louvain, Brussels, Belgium.

Country: ENGLAND

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MEDLINETA: Br J Ind Med

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