Assessment of thyroid function and urinary and breast milk iodine concentrations in healthy newborns and their mothers in Tehran.

Assessment of thyroid function and urinary and breast milk iodine concentrations in healthy newborns and their mothers in Tehran. Research Abstract Details 

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Assessment of thyroid function and urinary and breast milk iodine concentrations in healthy newborns and their mothers in Tehran. Abstract Text:

Arash Ordookhani,Elizabeth N Pearce,Mehdi Hedayati,Parvin Mirmiran,Sanam Salimi,Fereidoun Azizi,Lewis E Braverman,Arash Ordookhani,Elizabeth N Pearce,Mehdi Hedayati,Parvin Mirmiran,Sanam Salimi,Fereidoun Azizi,Lewis E Braverman,

OBJECTIVE: To measure breast milk iodine (MI) and urinary iodine (UI) concentrations in healthy newborns and their nursing mothers from an iodine-sufficient region to determine adequacy and to relate these parameters to thyroid function tests in mothers and infants. DESIGN: Cross-sectional. PATIENTS: Forty-eight healthy neonates of 37 to 42 weeks' gestation with normal cord blood TSH values and their mothers were recruited in Tehran, Iran. MEASUREMENTS: Serum thyroid function tests were performed, and maternal and infant urinary iodine excretion, and maternal MI concentration were measured. RESULTS: Neonatal age was 12.9 +/- 3.9 (mean +/- SD; range 7-30) days and maternal age was 25.8 +/- 5 years. Median (range) UI in neonates was 271 microg/l (57-800) and in mothers was 107 microg/l (20-710). Median (range) MI was 148 microg/l (45-750). Neonatal and maternal UI did not correlate with serum thyroid function tests. UI < 150, 150-230, and > 230 microg/l was found in 20, 12.5, and 67.5% of neonates and 79.1, 14, and 7% of mothers, respectively. MI was < 150, 150-180, and > 180 microg/l in 52.4, 11.9, and 35.7% of mothers, respectively. CONCLUSIONS: Among euthyroid neonates, UI was adequate despite low median maternal UI and MI concentrations. There were no significant correlations between UI or MI and thyroid function tests in the mothers and infants.

Assessment of thyroid function and urinary and breast milk iodine concentrations in healthy newborns and their mothers in Tehran. Publishing Authors By Initials

A Ordookhani,EN Pearce,M Hedayati,P Mirmiran,S Salimi,F Azizi,LE Braverman,A Ordookhani,EN Pearce,M Hedayati,P Mirmiran,S Salimi,F Azizi,LE Braverman,

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Assessment of thyroid function and urinary and breast milk iodine concentrations in healthy newborns and their mothers in Tehran. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Clinical endocrinology

VOLUME: 67

Page Numbers: 175-9

Journal Abbreviation: Clin. Endocrinol. (Oxf)

ISSN: 0300-0664

DAY: 27

MONTH: 04

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 346653

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Grant and Affiliation Information for Assessment of thyroid function and urinary and breast milk iodine concentrations in healthy newborns and their mothers in Tehran.

AFFILIATION: Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

Country: England

AGENCY: United States NIDDK

GRANT: 5K23 DK 4611

ACRONYM: DK

MEDLINETA: Clin Endocrinol (Oxf)

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