Assessment of human serotonin 1A receptor polymorphisms and SSRI responsiveness.

Assessment of human serotonin 1A receptor polymorphisms and SSRI responsiveness. Research Abstract Details 

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Assessment of human serotonin 1A receptor polymorphisms and SSRI responsiveness. Abstract Text:

Gary M Levin,Toya M Bowles,Megan J Ehret,Taimour Langaee,Jennifer Y Tan,Julie A Johnson,William J Millard,

BACKGROUND: Depression is thought to involve, in part, dysregulation of serotonergic neurotransmission. In depressed individuals, the number of serotonin receptors, including the 5-hydroxytryptamine (serotonin)-1A (5-HT(1A)) autoreceptors, are increased. Clinical improvement with selective serotonin reuptake inhibitors (SSRIs) is not usually observed until several weeks after treatment initiation. This delay may be due to the time it takes for the autoreceptors to downregulate. Roughly one-third of patients with depression do not respond to an initial trial of antidepressant medication treatment, possibly as a result of structural variations in the 5-HT(1A) receptor. AIMS: This study was designed to determine the allelic frequency of seven 5-HT(1A) receptor polymorphisms in a depressed versus a nondepressed population, and in SSRI responders versus nonresponders. All the polymorphisms studied are single nucleotide polymorphisms (SNPs) in the HTR1A gene, which encodes 5-HT(1A). Seven prevalent SNPs were included in the analysis. RESULTS: The study showed no relationship between any of the HTR1A polymorphisms and SSRI responders versus nonresponders. CONCLUSION: While the study has several limitations, the results are consistent with a growing body of literature that suggests that the pharmacogenetics of depression (an inherently complex disorder) may turn out to be multifactorial, and may include the HTR1A gene in concert with other serotonin-related genes.

Assessment of human serotonin 1A receptor polymorphisms and SSRI responsiveness. Publishing Authors By Initials

GM Levin,TM Bowles,MJ Ehret,T Langaee,JY Tan,JA Johnson,WJ Millard,

For similar chemical actions and uses: pharmacologic actions: molecular mechanisms of pharmacological action: neurotransmitter agents: neurotransmitter uptake inhibitors: serotonin uptake inhibitors research abstracts see: chemical actions and uses: pharmacologic actions: molecular mechanisms of pharmacological action: neurotransmitter agents: neurotransmitter uptake inhibitors: serotonin uptake inhibitors research

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MEDLINE DATE:

Assessment of human serotonin 1A receptor polymorphisms and SSRI responsiveness. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular diagnosis & therapy

VOLUME: 11

Page Numbers: 155-60

Journal Abbreviation:

ISSN: 1177-1062

DAY: 3

MONTH: 12

YEAR: 2007

Assessment of human serotonin 1A receptor polymorphisms and SSRI responsiveness. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101264260

Assessment of human serotonin 1A receptor polymorphisms and SSRI responsiveness. Keywords Mesh Terms:

KEYWORDS: Serotonin Uptake Inhibitors

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Assessment of human serotonin 1A receptor polymorphisms and SSRI responsiveness. Information

Substance Name: Receptor, Serotonin, 5-HT1A

Registry Number: 112692-38-3

Grant and Affiliation Information for Assessment of human serotonin 1A receptor polymorphisms and SSRI responsiveness.

AFFILIATION: College of Pharmacy, University of Florida, Gainesville, Florida, USA. glevin@lecom.edu

Country: New Zealand

AGENCY: United States NIA

GRANT: AG 10485

ACRONYM: AG

MEDLINETA: Mol Diagn Ther

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