Assessment of bleeding after concomitant administration of antiplatelet and anticoagulant agents in lower limb arthroplasty.

Assessment of bleeding after concomitant administration of antiplatelet and anticoagulant agents in lower limb arthroplasty. Research Abstract Details 

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Assessment of bleeding after concomitant administration of antiplatelet and anticoagulant agents in lower limb arthroplasty. Abstract Text:

Ola E Dahl,Mats Ogren,Giancarlo Agnelli,Bengt I Eriksson,Alexander T Cohen,Patrick Mouret,Nadia Rosencher,Anders Bylock,Seva Panfilov,Magnus Andersson,Ola E Dahl,Mats Ogren,Giancarlo Agnelli,Bengt I Eriksson,Alexander T Cohen,Patrick Mouret,Nadia Rosencher,Anders Bylock,Seva Panfilov,Magnus Andersson,

In an analysis of the Melagatran Thrombosis Prophylaxis in Orthopedic Surgery (METHRO) III study, we evaluated whether concomitant administration of aspirin (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs) with the direct thrombin inhibitor melagatran/ximelagatran or the low-molecular-weight heparin enoxaparin increased bleeding in patients undergoing major joint surgery. Further objectives were to compare the influence of the timing of initial postoperative administration of melagatran/ximelagatran on bleeding in orthopedic patients receiving ASA/NSAIDs and in comparison with the preoperative administration of enoxaparin. ASA or NSAIDs in conjunction with melagatran/ximelagatran or enoxaparin did not increase bleeding. Bleeding rates were not significantly different, irrespective of the timing of the initial postoperative dose of melagatran/ximelagatran (4-8 vs. 4-12 h) when compared with preoperative (12 h) administration of enoxaparin. Transfusion rates were significantly lower with administration of melagatran/ximelagatran compared with enoxaparin.

Assessment of bleeding after concomitant administration of antiplatelet and anticoagulant agents in lower limb arthroplasty. Publishing Authors By Initials

OE Dahl,M Ogren,G Agnelli,BI Eriksson,AT Cohen,P Mouret,N Rosencher,A Bylock,S Panfilov,M Andersson,OE Dahl,M Ogren,G Agnelli,BI Eriksson,AT Cohen,P Mouret,N Rosencher,A Bylock,S Panfilov,M Andersson,

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Assessment of bleeding after concomitant administration of antiplatelet and anticoagulant agents in lower limb arthroplasty. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pathophysiology of haemostasis and thrombosis

VOLUME: 35

Page Numbers: 428-34

Journal Abbreviation: Pathophysiol. Haemost. Thromb.

ISSN: 1424-8832

DAY: 13

MONTH: 06

YEAR: 2006

Assessment of bleeding after concomitant administration of antiplatelet and anticoagulant agents in lower limb arthroplasty. Information

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LANGUAGE: eng

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AFFILIATION: International Surgical Thrombosis Forum, Thrombosis Research Institute, London, UK. oladahl@start.no

Country: Switzerland

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MEDLINETA: Pathophysiol Haemost Thromb

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