Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of ebola virus hemorrhagic Fever.

Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of ebola virus hemorrhagic Fever. Research Abstract Details 

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Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of ebola virus hemorrhagic Fever. Abstract Text:

Steven M Jones,Ute Stroher,Lisa Fernando,Xianggou Qiu,Judie Alimonti,Pasquale Melito,Mike Bray,Hans-Dieter Klenk,Heinz Feldmann,Steven M Jones,Ute Stroher,Lisa Fernando,Xianggou Qiu,Judie Alimonti,Pasquale Melito,Mike Bray,Hans-Dieter Klenk,Heinz Feldmann,Steven M Jones,Ute Stroher,Lisa Fernando,Xianggou Qiu,Judie Alimonti,Pasquale Melito,Mike Bray,Hans-Dieter Klenk,Heinz Feldmann,

Background. In humans and nonhuman primates, Ebola virus causes a virulent viral hemorrhagic fever for which no licensed vaccines or therapeutic drugs exist. In the present study, we used the mouse model for Ebola hemorrhagic fever to assess the safety and efficacy of a vaccine based on a live attenuated vesicular stomatitis virus expressing the Zaire ebolavirus (ZEBOV) glycoprotein.Methods. Healthy mice were given the vaccine in various doses, decreasing from 2x104 to 2 plaque-forming units (pfu), with both systemic and mucosal vaccination routes used. Mice were challenged with 103 to 106 lethal doses of mouse-adapted ZEBOV. Severely immunocompromised mice were injected with 2x105 pfu, which is 10 times greater than the immunization dose normally used, to test vaccine safety.Results. Two plaque-forming units of the vaccine protected against lethal challenge, and mucosal immunization was found to be as protective as systemic injection. The replicating vaccine was never detected in the immunized animals, nor were there clinical signs after immunization. Immunization of severely immunocompromised mice with 200,000 pfu of vaccine resulted in no clinical symptoms.Conclusions. Our data suggest that the vaccine is highly potent and safe and that it very rapidly induces "sterile" immunity in mice. The potential for mucosal delivery, if confirmed in nonhuman primates, makes it an excellent candidate for mass immunization during outbreaks or in the event of intentional release.

Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of ebola virus hemorrhagic Fever. Publishing Authors By Initials

SM Jones,U Stroher,L Fernando,X Qiu,J Alimonti,P Melito,M Bray,HD Klenk,H Feldmann,SM Jones,U Stroher,L Fernando,X Qiu,J Alimonti,P Melito,M Bray,HD Klenk,H Feldmann,SM Jones,U Stroher,L Fernando,X Qiu,J Alimonti,P Melito,M Bray,HD Klenk,H Feldmann,

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Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of ebola virus hemorrhagic Fever. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of infectious diseases

VOLUME: 196 Suppl 2

Page Numbers: S404-12

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 15

MONTH: Nov

YEAR: 2007

Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of ebola virus hemorrhagic Fever. Information

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LANGUAGE: eng

NlmUniqueID: 413675

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AFFILIATION: Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canad, Manitoba, R3E 3R2, Canada. Steven_jones@phac-aspc.gc.ca.

Country: United States

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MEDLINETA: J Infect Dis

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