Assessing vaccine efficacy for the prevention of acute otitis media by pneumococcal vaccination in children: a methodological overview of statistical practice in randomized controlled clinical trials.

Assessing vaccine efficacy for the prevention of acute otitis media by pneumococcal vaccination in children: a methodological overview of statistical practice in randomized controlled clinical trials. Research Abstract Details 

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Assessing vaccine efficacy for the prevention of acute otitis media by pneumococcal vaccination in children: a methodological overview of statistical practice in randomized controlled clinical trials. Abstract Text:

Antje Jahn-Eimermacher,Jean-Baptist du Prel,Heinz-Josef Schmitt,Antje Jahn-Eimermacher,Jean-Baptist du Prel,Heinz-Josef Schmitt,

Acute otitis media (AOM) is the most common bacterial infectious disease among children. Vaccination is proposed to prevent otitis and several clinical trials were performed to assess the efficacy of pneumococcal vaccines. The way vaccine efficacy is analysed varies among trials. However, the clinical meaning of an estimate of vaccine effect and its statistical test depends on the applied statistical method. We aim to bring the meaning and validity of statistical trial results to the attention of researchers. We consider all methodological approaches for analysing vaccine efficacy applied in pneumococcal vaccination trials included in a recent Cochrane Review. We demonstrate how different methods address different scientific questions on the effect of vaccination, how they can complement each other and why some methods can produce misleading results.

Assessing vaccine efficacy for the prevention of acute otitis media by pneumococcal vaccination in children: a methodological overview of statistical practice in randomized controlled clinical trials. Publishing Authors By Initials

A Jahn-Eimermacher,JB du Prel,HJ Schmitt,A Jahn-Eimermacher,JB du Prel,HJ Schmitt,

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Assessing vaccine efficacy for the prevention of acute otitis media by pneumococcal vaccination in children: a methodological overview of statistical practice in randomized controlled clinical trials. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Vaccine

VOLUME: 25

Page Numbers: 6237-44

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 18

MONTH: 06

YEAR: 2007

Assessing vaccine efficacy for the prevention of acute otitis media by pneumococcal vaccination in children: a methodological overview of statistical practice in randomized controlled clinical trials. Information

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LANGUAGE: eng

NlmUniqueID: 8406899

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Grant and Affiliation Information for Assessing vaccine efficacy for the prevention of acute otitis media by pneumococcal vaccination in children: a methodological overview of statistical practice in randomized controlled clinical trials.

AFFILIATION: Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University of Mainz, 55101 Mainz, Germany. jahn@imbei.uni-mainz.de

Country: Netherlands

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MEDLINETA: Vaccine

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