Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: Application in pharmacokinetics.

Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: Application in pharmacokinetics. Research Abstract Details 

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Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: Application in pharmacokinetics. Abstract Text:

S H Hansen,S B Pedersen,

An LC method able to separate all known metabolites of tolfenamic acid was developed. It was applied to characterize the metabolic profiles after single and multiple peroral doses of tolfenamic acid to volunteers. Up to 80% of the dose, mostly conjugated metabolites, could be recovered in the urine by this method. Two of the metabolites showed plasma half-lives of several days and peculiar conjugation properties.

Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: Application in pharmacokinetics. Publishing Authors By Initials

SH Hansen,SB Pedersen,

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Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: Application in pharmacokinetics. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 4

Page Numbers: 69-82

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ISSN: 0731-7085

DAY: 26

MONTH: 07

YEAR: 1986

Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: Application in pharmacokinetics. Information

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LANGUAGE: eng

NlmUniqueID: 8309336

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Grant and Affiliation Information for Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: Application in pharmacokinetics.

AFFILIATION: Department of Organic Chemistry, Royal Danish School of Pharmacy, 2 Universitetsparken, DK-2100 Copenhagen, Denmark.

Country: England

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MEDLINETA: J Pharm Biomed Anal

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