Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori.

Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori. Research Abstract Details 

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Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori. Abstract Text:

Minoru Fukuda,Masatomo Kawakubo,Yuki Ito,Motohiro Kobayashi,Heeseob Lee,Jun Nakayama,

Helicobacter pylori infects more than half of the world's population and is considered a leading cause of peptic ulcer and gastric carcinoma. Although a large number of persons are infected with H. pylori, only a limited number of those infected (approximately 3%) develop peptic ulcers and gastric carcinoma. The progression of the disease is restricted by deeper portion of the gastric mucosa, and in many persons glandular atrophy appears to be prevented by mucins secreted in the deeper portion of the mucosa. Recent studies have shown that this inhibitory activity is at least partly due to the expression of alpha1,4-N-acetylglucosamine residues attached to the mucin (MUC6) in the deeper portion of the mucosa. alpha1,4-N-acetylglucosamine residues inhibit cholesterol alpha-glucosyltransferase, the product of which constitutes a major component of H. pylori cell wall. This inhibitory activity is thus regarded as a natural antibiotic function. This chapter describes the assay for antibiotic activity of MUC6 mucin against H. pylori infection and growth as well as inhibition by alpha1,4-N-acetylglucosamine-capped mucin-type oligosaccharides.

Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori. Publishing Authors By Initials

M Fukuda,M Kawakubo,Y Ito,M Kobayashi,H Lee,J Nakayama,

For similar mucoproteins: mucins research abstracts see: mucoproteins: mucins research

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Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Methods in enzymology

VOLUME: 415

Page Numbers: 164-79

Journal Abbreviation: Meth. Enzymol.

ISSN: 0076-6879

DAY: 3

MONTH: 12

YEAR: 2006

Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 212271

Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori. Keywords Mesh Terms:

KEYWORDS: Mucins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori. Information

Substance Name: Glucosyltransferases

Registry Number: EC 2.4.1.-

Grant and Affiliation Information for Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori.

AFFILIATION: Glycobiology Program, Cancer Research Center, The Burnham Institute for Medical Research, La Jolla, CA, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA33000

ACRONYM: CA

MEDLINETA: Methods Enzymol

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