Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits.

Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits. Research Abstract Details 

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Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits. Abstract Text:

A M Roberton,B Rabel,L Stubbs,C Tasman-Jones,S P Lee,

The effect of aspirin on the rate of secretion and amino acid composition of human ileal mucin was studied, using subjects with ileal conduits as a model system in which mucin secreted from the ileal conduit tissue is flushed out in the urine and can be measured and analysed. Aspirin (600 mg per day, administered orally) increased the daily mucin output by 37-104% in subjects by days 3 or 4, but thereafter the mucin output declined to below the baseline level by day 10. Mucin samples, purified from the ileal conduit urine during the control period and during aspirin administration, were compared. There were no discernible changes in the degree of polymerisation or the density, but during aspirin administration the amino acid composition was significantly changed, and in particular threonine and proline were enriched. One possible explanation, consistent with the compositional analyses, is that the N- and C-terminal regions of the mucin subunits have been cleaved off and lost during aspirin administration. The observed changes in mucin secretion may have implications for the mechanism of the toxic effects of aspirin on the small intestine by altering the barrier properties of the mucus layer.

Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits. Publishing Authors By Initials

AM Roberton,B Rabel,L Stubbs,C Tasman-Jones,SP Lee,

For similar surgical procedures, operative: urogenital surgical procedures: urologic surgical procedures: urinary diversion research abstracts see: surgical procedures, operative: urogenital surgical procedures: urologic surgical procedures: urinary diversion research

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Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Glycoconjugate journal

VOLUME: 13

Page Numbers: 781-9

Journal Abbreviation: Glycoconj. J.

ISSN: 0282-0080

DAY: 30

MONTH: Oct

YEAR: 1996

Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits. Information

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LANGUAGE: eng

NlmUniqueID: 8603310

Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits. Keywords Mesh Terms:

KEYWORDS: Urinary Diversion

MESH TERMS: urine

Chemical & Substance for Abstract: Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits. Information

Substance Name: cesium chloride

Registry Number: 7647-17-8

Grant and Affiliation Information for Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits.

AFFILIATION: School of Biological Sciences, University of Auckland, New Zealand.

Country: ENGLAND

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MEDLINETA: Glycoconj J

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