Aspirin and folic acid for the prevention of recurrent colorectal adenomas.

Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Research Abstract Details 

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Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Abstract Text:

Richard F A Logan,Matthew J Grainge,Vic C Shepherd,Nicholas C Armitage,Kenneth R Muir, ,Richard F A Logan,Matthew J Grainge,Vic C Shepherd,Nicholas C Armitage,Kenneth R Muir, ,Richard F A Logan,Matthew J Grainge,Vic C Shepherd,Nicholas C Armitage,Kenneth R Muir, ,

BACKGROUND & AIMS: Although observational studies have found regular aspirin use to be associated with a reduced risk of colorectal neoplasia, results from randomized trials using aspirin have been inconsistent. Dietary folate intake also has been found to be associated with a reduced risk of colorectal neoplasms in observational studies. METHODS: A multicenter, randomized, double-blind trial of aspirin (300 mg/day) and folate supplements (0.5 mg/day) to prevent colorectal adenoma recurrence was performed using a 2 x 2 factorial design. All patients had an adenoma (>/=0.5 cm) removed in the 6 months before recruitment and were followed-up at 4-month intervals with a second colonoscopy after approximately 3 years. The primary outcome measure was a colorectal adenoma diagnosed after baseline. RESULTS: A total of 945 patients were recruited into the study, of whom 853 (90.3%) underwent a second colonoscopy. In total, 99 (22.8%) of 434 patients receiving aspirin had a recurrent adenoma compared with 121 (28.9%) of 419 patients receiving placebo (relative risk, 0.79; 95% confidence interval [CI], 0.63-0.99). A total of 104 patients developed an advanced colorectal adenoma; 41 (9.4%) of these were in the aspirin group and 63 (15.0%) were in the placebo group (relative risk, 0.63; 95% CI, 0.43-0.91). Folate supplementation was found to have no effect on adenoma recurrence (relative risk, 1.07; 95% CI, 0.85-1.34). CONCLUSIONS: Aspirin (300 mg/day) but not folate (0.5 mg/day) use was found to reduce the risk of colorectal adenoma recurrence, with evidence that aspirin could have a significant role in preventing the development of advanced lesions.

Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Publishing Authors By Initials

RF Logan,MJ Grainge,VC Shepherd,NC Armitage,KR Muir, ,RF Logan,MJ Grainge,VC Shepherd,NC Armitage,KR Muir, ,RF Logan,MJ Grainge,VC Shepherd,NC Armitage,KR Muir, ,

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Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gastroenterology

VOLUME: 134

Page Numbers: 29-38

Journal Abbreviation: Gastroenterology

ISSN: 1528-0012

DAY: 10

MONTH: 10

YEAR: 2007

Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Information

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LANGUAGE: eng

NlmUniqueID: 374630

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AFFILIATION: Division of Epidemiology and Public Health, University of Nottingham, University Hospital, Nottingham, United Kingdom. Richard.Logan@nottingham.ac.uk

Country: United States

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MEDLINETA: Gastroenterology

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