Asiatic acid and corosolic acid enhance the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin.

Asiatic acid and corosolic acid enhance the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin. Research Abstract Details 

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Asiatic acid and corosolic acid enhance the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin. Abstract Text:

Eliane Garo,Gary R Eldridge,Matt G Goering,Elinor DeLancey Pulcini,Martin A Hamilton,John W Costerton,Garth A James,

Asiatic acid and corosolic acid are two natural products identified as biofilm inhibitors in a biofilm inhibition assay. We evaluated the activities of these two compounds on Pseudomonas aeruginosa biofilms grown in rotating disk reactors (RDRs) in combination with tobramycin and ciprofloxacin. To determine the ruggedness of our systems, the antibiotic susceptibilities of these biofilms were assessed with tobramycin and ciprofloxacin. The biofilm bacteria produced in the RDR were shown to display remarkable tolerance to 10 mug/ml of ciprofloxacin, thus mimicking the tolerance observed in recalcitrant bacterial infections. These studies further demonstrate that a nonmucoid strain of P. aeruginosa can form a biofilm that tolerates ciprofloxacin at clinically relevant concentrations. Neither asiatic acid nor corosolic acid reduced the viable cell density of P. aeruginosa biofilms. However, both compounds increased the susceptibility of biofilm bacteria to subsequent treatment with tobramycin, suggesting asiatic acid and corosolic acid to be compounds that potentiate the activity of antibiotics. A similar statistical interaction was observed between ciprofloxacin and subsequent treatment with tobramycin.

Asiatic acid and corosolic acid enhance the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin. Publishing Authors By Initials

E Garo,GR Eldridge,MG Goering,E DeLancey Pulcini,MA Hamilton,JW Costerton,GA James,

For similar organic chemicals: hydrocarbons: terpenes: triterpenes research abstracts see: organic chemicals: hydrocarbons: terpenes: triterpenes research

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Asiatic acid and corosolic acid enhance the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Antimicrobial agents and chemotherapy

VOLUME: 51

Page Numbers: 1813-7

Journal Abbreviation:

ISSN: 0066-4804

DAY: 12

MONTH: 03

YEAR: 2007

Asiatic acid and corosolic acid enhance the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 315061

Asiatic acid and corosolic acid enhance the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin. Keywords Mesh Terms:

KEYWORDS: Triterpenes

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Asiatic acid and corosolic acid enhance the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin. Information

Substance Name: Ciprofloxacin

Registry Number: 85721-33-1

Grant and Affiliation Information for Asiatic acid and corosolic acid enhance the susceptibility of Pseudomonas aeruginosa biofilms to tobramycin.

AFFILIATION: Sequoia Sciences Inc, Saint Louis, MO 63114, USA. egaro@sequoiasciences.com

Country: United States

AGENCY: United States NCRR

GRANT: R42 RR016363-02

ACRONYM: RR

MEDLINETA: Antimicrob Agents Chemother

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