Ascorbic acid and reducing agents regulate the fates and functions of S-nitrosothiols.

Ascorbic acid and reducing agents regulate the fates and functions of S-nitrosothiols. Research Abstract Details 

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Ascorbic acid and reducing agents regulate the fates and functions of S-nitrosothiols. Abstract Text:

M Kashiba-Iwatsuki,K Kitoh,E Kasahara,H Yu,M Nisikawa,M Matsuo,M Inoue,

Although S-nitrosoglutathione (GS-NO) and other S-nitrosothiols (RS-NO) exhibit activity attributable to nitric oxide (NO), the dynamic aspects of their metabolism remain to be elucidated. To determine the fates and functions of RS-NO, the stability of GS-NO was analyzed in plasma, and various fractions of liver and kidney. GS-NO was fairly stable under physiological conditions in plasma and buffer solutions. However, GS-NO was rapidly decomposed in the presence of either homogenates of rat liver and kidney or their supernatant fractions. The ability of the supernatants to decompose GS-NO remained unchanged after the removal of proteins and large molecular weight compounds. Physiological levels of reducing agents, such as reduced glutathione (GSH), ascorbic acid (AsA), and cysteine, also enhanced the decomposition of RS-NO; the order of their potency was AsA > cysteine >GSH. Considering their intra-cellular concentrations and potency, AsA might principally be responsible for the enhanced decomposition of GS-NO. NO, GS-NO, and related RS-NO inhibited the respiration of Ehrlich ascites tumor cells. The inhibitory effect of GS-NO was enhanced by the reducing agents (cysteine>AsA>GSH). Intravenously administered GS-NO exhibited a depressor action through some ascorbic acid enhancable mechanism. Thus, the metabolism and biological function of GS-NO and related RS-NO might be affected by AsA and other reducing agents.

Ascorbic acid and reducing agents regulate the fates and functions of S-nitrosothiols. Publishing Authors By Initials

M Kashiba-Iwatsuki,K Kitoh,E Kasahara,H Yu,M Nisikawa,M Matsuo,M Inoue,

For similar sulfhydryl compounds research abstracts see: sulfhydryl compounds research

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Ascorbic acid and reducing agents regulate the fates and functions of S-nitrosothiols. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 122

Page Numbers: 1208-14

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Dec

YEAR: 1997

Ascorbic acid and reducing agents regulate the fates and functions of S-nitrosothiols. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Ascorbic acid and reducing agents regulate the fates and functions of S-nitrosothiols. Keywords Mesh Terms:

KEYWORDS: Sulfhydryl Compounds

MESH TERMS: physiology

Chemical & Substance for Abstract: Ascorbic acid and reducing agents regulate the fates and functions of S-nitrosothiols. Information

Substance Name: Glutathione

Registry Number: 70-18-8

Grant and Affiliation Information for Ascorbic acid and reducing agents regulate the fates and functions of S-nitrosothiols.

AFFILIATION: Department of Biochemistry, Osaka City University Medical School, Osaka.

Country: JAPAN

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MEDLINETA: J Biochem

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