Artificial selection for increased maternal defense behavior in mice.

Artificial selection for increased maternal defense behavior in mice. Research Abstract Details 

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Artificial selection for increased maternal defense behavior in mice. Abstract Text:

Stephen C Gammie,Theodore Garland,Sharon A Stevenson,

Maternal aggression is directed towards intruders by lactating females and is critical for defense of offspring. Within-family selection for increased maternal defense in outbred house mice (Mus domesticus; Hsd:ICR strain) was applied to one selected (S) line, using total duration of attacks in a 3-min test as the selection criterion. One control (C) line was maintained and both lines were propagated by 13 families in each generation. Prior to selection, heritability of maternal aggression was estimated to be 0.61 based on mother-offspring regression. Duration of attacks responded to selection with a mean realized heritability of 0.40 (corrected for within-family selection) after eight generations. At generation 5, the S and C line also differed significantly for litter size at birth and at mid-lactation (both lower in S), average individual pup mass at midlactation (higher in S), and pup retrieval latency (longer in S), but not for other maternal measures that we studied (e.g., dam mass). Additionally, number of entries to middle and closed plus maze compartments was significantly higher in S mice in Generation 5. This is the first study to select for high maternal defense and these mice will be made available as a tool for understanding the genetic and neural basis of maternal aggression.

Artificial selection for increased maternal defense behavior in mice. Publishing Authors By Initials

SC Gammie,T Garland,SA Stevenson,

For similar genetic processes: selection (genetics) research abstracts see: genetic processes: selection (genetics) research

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Artificial selection for increased maternal defense behavior in mice. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Behavior genetics

VOLUME: 36

Page Numbers: 713-22

Journal Abbreviation: Behav. Genet.

ISSN: 0001-8244

DAY: 3

MONTH: Sep

YEAR: 2006

Artificial selection for increased maternal defense behavior in mice. Information

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LANGUAGE: eng

NlmUniqueID: 251711

Artificial selection for increased maternal defense behavior in mice. Keywords Mesh Terms:

KEYWORDS: Selection (Genetics)

MESH TERMS: physiology

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Grant and Affiliation Information for Artificial selection for increased maternal defense behavior in mice.

AFFILIATION: Department of Zoology, University of Wisconsin, 1117 West Johnson St., Madison, WI 53706, USA. scgammie@wisc.edu

Country: United States

AGENCY: United States NIMH

GRANT: R01 MH066086

ACRONYM: MH

MEDLINETA: Behav Genet

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