Artemisinin, Related Sesquiterpenes, and Essential Oil in Artemisia annua During a Vegetation Period in Vietnam.

Artemisinin, Related Sesquiterpenes, and Essential Oil in Artemisia annua During a Vegetation Period in Vietnam. Research Abstract Details 

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Artemisinin, Related Sesquiterpenes, and Essential Oil in Artemisia annua During a Vegetation Period in Vietnam. Abstract Text:

H J Woerdenbag,N Pras,N G Chan,B T Bang,R Bos,W van Uden,P Van Y,N Van Boi,S Batterman,C B Lugt,

The active principle of ARTEMISIA ANNUA L., artemisinin, is currently being developed to a registered antimalarial drug. For production purposes, plants with a high artemisinin content are required. We followed the development of the artemisinin content and of the biosynthetically related sesquiterpenes artemisinic acid, arteannuin B, and artemisitene in A. ANNUA plants, during a vegetation period in Vietnam, where this species is indigenous. In addition, the essential oil content and composition were studied. Samples of leaves, buds, flowers, or post-bloom flowers and fruits were taken at different stages: vegetative (5, 6, and 8 months old), at mass formation of buds (9 months), at full bloom (10 months), and post-bloom (10S months). The highest artemisinin content (0.86% dry wt) was present in the leaves of 5 months-old plants. At this stage also the highest leaf yield was found. Subsequently, the artemisinin content gradually dropped. At the age of 5 months the highest artemisinic acid and arteannuin B contents, 0.16 and 0.08% dry wt, respectively, were found as well. Artemisitene was present at all stages of development, ranging from 0.002 to 0.09% dry wt. With 1.9% v/w, the essential oil content was maximal just before flowering and was composed of 55% monoterpenes and 45% sesquiterpenes. At all other stages (0.4 - 1.0% v/w oil) this ratio was ca. 30%/70%. The main components of the oil were camphor and germacrene-D.

Artemisinin, Related Sesquiterpenes, and Essential Oil in Artemisia annua During a Vegetation Period in Vietnam. Publishing Authors By Initials

HJ Woerdenbag,N Pras,NG Chan,BT Bang,R Bos,W van Uden,P Van Y,N Van Boi,S Batterman,CB Lugt,

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Artemisinin, Related Sesquiterpenes, and Essential Oil in Artemisia annua During a Vegetation Period in Vietnam. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Planta medica

VOLUME: 60

Page Numbers: 272-5

Journal Abbreviation: Planta Med.

ISSN: 0032-0943

DAY: 19

MONTH: Jun

YEAR: 1994

Artemisinin, Related Sesquiterpenes, and Essential Oil in Artemisia annua During a Vegetation Period in Vietnam. Information

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LANGUAGE: eng

NlmUniqueID: 66751

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AFFILIATION: Department of Pharmacential Biology, University Centre for Pharmacy, University of Groningen, A. Deusinglaan 2, NL-9713 AW Groningen, The Netherlands.

Country: Germany

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MEDLINETA: Planta Med

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