[Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1]

[Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1] Research Abstract Details 

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[Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1] Abstract Text:

Hongyan Tong,Maofang Lin,

OBJECTIVE: To investigate the mechanisms of arsenic trioxide (As(2)O(3)) induced demethylation. METHOD: Methylation of p15INK4B gene in MUTZ-1 cell was detected by PCR using a methylation specific primer (MSP), the expression of P15, DNA methyltransferase (DNMT) 1, DNMT3A and DNMT3B gene by RT-PCR, the As(2)O(3) induced growth inhibition of MUTZ-1 cell by MTT method. RESULTS: P15 gene failed to express in MUTZ-1 cells after methylation. The expression was recovered after the cells exposed to As(2)O(3). As(2)O(3) could significantly down-regulate DNMT3A and DNMT3B but not DNMT1 gene on mRNA level in a dose dependent manner. CONCLUSION: As(2)O(3) could activate the expression of p15 gene by demethylation or/and by inhibiting DNMT3A and DNMT3B gene.

[Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1] Publishing Authors By Initials

H Tong,M Lin,

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[Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 23

Page Numbers: 638-41

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 1

MONTH: Dec

YEAR: 2002

[Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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Grant and Affiliation Information for [Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1]

AFFILIATION: The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310003, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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