Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh.

Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Research Abstract Details 

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Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Abstract Text:

Habibul Ahsan,Yu Chen,Muhammad G Kibriya,Vesna Slavkovich,Faruque Parvez,Farzana Jasmine,Mary V Gamble,Joseph H Graziano,

We conducted a case-control study to investigate interindividual variability in susceptibility to health effects of inorganic arsenic due to arsenic metabolism efficiency, genetic factors, and their interaction. A total of 594 cases of arsenic-induced skin lesions and 1,041 controls was selected from baseline participants in a large prospective cohort study in Bangladesh. Adjusted odds ratios (OR) for skin lesions were estimated in relation to the polymorphisms in the glutathione S-transferase omega1 and methylenetetrahydrofolate reductase genes, the percentage of monomethylarsonous acid (%MMA) and dimethylarsinic acid (%DMA) in urine, and the ratios of MMA to inorganic arsenic and DMA to MMA. Water arsenic concentration was positively associated with %MMA and inversely associated with %DMA. The dose-response relationship of risk of skin lesion with %MMA was more apparent than those with other methylation indices; the ORs for skin lesions in relation to increasing %MMA quartiles were 1.00 (reference), 1.33 [95% confidence interval (95% CI), 0.92-1.93], 1.68 (95% CI, 1.17-2.42), and 1.57 (95% CI, 1.10-2.26; P for trend = 0.01). The ORs for skin lesions in relation to the methylenetetrahydrofolate reductase 677TT/1298AA and 677CT/1298AA diplotypes (compared with 677CC/1298CC diplotype) were 1.66 (95% CI, 1.00-2.77) and 1.77 (95% CI, 0.61-5.14), respectively. The OR for skin lesions in relation to the glutathione S-transferase omega1 diplotype containing all at-risk alleles was 3.91 (95% CI, 1.03-14.79). Analysis of joint effects of genotypes/diplotypes with water arsenic concentration and urinary %MMA suggests additivity of these factors. The findings suggest that arsenic metabolism, particularly the conversion of MMA to DMA, may be saturable and that differences in urinary arsenic metabolites, genetic factors related to arsenic metabolism, and their joint distributions modulate arsenic toxicity.

Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Publishing Authors By Initials

H Ahsan,Y Chen,MG Kibriya,V Slavkovich,F Parvez,F Jasmine,MV Gamble,JH Graziano,

For similar environmental pollution: water pollution: water pollution, chemical research abstracts see: environmental pollution: water pollution: water pollution, chemical research

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Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 16

Page Numbers: 1270-8

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 3

MONTH: Jun

YEAR: 2007

Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Information

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LANGUAGE: eng

NlmUniqueID: 9200608

Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Keywords Mesh Terms:

KEYWORDS: Water Pollution, Chemical

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Information

Substance Name: Glutathione Transferase

Registry Number: EC 2.5.1.18

Grant and Affiliation Information for Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh.

AFFILIATION: Departments of Epidemiology, Columbia University, USA. habib@uchicago.edu

Country: United States

AGENCY: United States NCI

GRANT: R01CA107431

ACRONYM: CA

MEDLINETA: Cancer Epidemiol Biomarkers Pr

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