Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion.

Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion. Research Abstract Details 

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Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion. Abstract Text:

Wenjie He,Robert J Greenwell,Diane M Brooks,Lilian ,Howard D Beall,J Douglas Coffin,

Arsenic is an abundant toxicant in ground water and soil around areas with extractive industries. Human epidemiological studies have shown that arsenic exposure is linked to developmental defects and miscarriage. The placenta is known to utilize vasculogenesis to develop its circulation. The hypothesis tested here states the following: arsenic exposure causes placental dysmorphogenesis and defective placental vasculogenesis resulting in placental insufficiency and subsequent spontaneous abortion. To test this hypothesis, pregnant mice were exposed to sodium arsenite (AsIII) through drinking water from conception through weanling stages. Neonatal assessment of birth rates, pup weights, and litter sizes in arsenic exposed and control mothers revealed that AsIII-exposed mothers had only 40% the fecundity of controls. Preterm analysis at E12.5 revealed a loss of fecundity at E12.5 from either 20 ppm or greater exposures to AsIII. There was no loss of fecundity at E7.5 suggesting that spontaneous abortion occurs during placentation. Histomorphometry on E12.5 placentae from arsenic-exposed mice revealed placental dysplasia especially in the vasculature. These results suggest that arsenic toxicity is causative for mammalian spontaneous abortion by virtue of aberrant placental vasculogenesis and placental insufficiency.

Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion. Publishing Authors By Initials

W He,RJ Greenwell,DM Brooks,L ,HD Beall,JD Coffin,

For similar inorganic chemicals: sodium compounds research abstracts see: inorganic chemicals: sodium compounds research

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MEDLINE DATE:

Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Toxicological sciences : an official journal of th

VOLUME: 99

Page Numbers: 244-53

Journal Abbreviation: Toxicol. Sci.

ISSN: 1096-6080

DAY: 14

MONTH: 06

YEAR: 2007

Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9805461

Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion. Keywords Mesh Terms:

KEYWORDS: Sodium Compounds

MESH TERMS: toxicity

Chemical & Substance for Abstract: Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion. Information

Substance Name: sodium arsenite

Registry Number: 13768-07-5

Grant and Affiliation Information for Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion.

AFFILIATION: Department of Biomedical and Pharmaceutical Sciences and Center for Environmental Health Sciences, The University of Montana, Missoula, Montana 59812, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: R21ES01174902

ACRONYM: ES

MEDLINETA: Toxicol Sci

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