Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages.

Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages. Abstract Text:

E A Machado,D A Gerard,J R Mitchell,B B Lozzio,C B Lozzio,

The morphological aspects of the arrest and extravasation of malignant cells of human origin (K-562 cell line) in the lungs of athymic (nude) and asplenic-athymic (lasat) mice were studied by electron microscopy examination of serial sections. The specimens were obtained at sequential stages after the sc inoculation into newborn mice of 10(7) malignant cells. K-562 cells (10(5)) were also injected iv into control groups of nude and lasat mice to assess the influence of the route of inoculation on the in vivo behavior of K-562 cells. Our results demonstrated that K-562 cells were arrested and proliferated within the pulmonary capillaries without the participation of platelets or fibrin. The neoplastic cells extravasated by attrition and penetration of the endothelium (rather than by diapedesis) and continued to proliferate in the interstitial tissue of the lung, developing into neoplastic nodules. Following iv injection, K-562 cells induced the formation of platelet-tumor cell aggregates within the pulmonary capillaries. However, under these conditions, the neoplastic cells did not adhere to the endothelium nor did they proliferate or extravasate. These aggregates were flushed out by the circulation, restoring the permeability of the capillaries.

Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages. Publishing Authors By Initials

EA Machado,DA Gerard,JR Mitchell,BB Lozzio,CB Lozzio,

For similar neoplasms: neoplasms, experimental research abstracts see: neoplasms: neoplasms, experimental research

PUBMED ID PMID:

MEDLINE DATE:

Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Virchows Archiv. A, Pathological anatomy and histo

VOLUME: 396

Page Numbers: 73-89

Journal Abbreviation:

ISSN: 0340-1227

DAY: 20

MONTH: 02

YEAR: 1982

Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505137

Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages. Keywords Mesh Terms:

KEYWORDS: Neoplasms, Experimental

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages. Information

Substance Name: Fibrin

Registry Number: 9001-31-4

Grant and Affiliation Information for Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages.

AFFILIATION:

Country: GERMANY, WEST

AGENCY: United States PHS

GRANT: FR 5541

ACRONYM: CA

MEDLINETA: Virchows Arch A Pathol Anat Hi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Arrest and extravasation of neoplastic cells An electron microscopy study of serial sections at sequential stages Related Publications

• Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages.