ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity.

ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity. Research Abstract Details 

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ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity. Abstract Text:

M Srivastava,H Scherr,M Lackey,D Xu,Z Chen,J Lu,A Bergmann,

In mammals and Drosophila, apoptotic caspases are under positive control of the CED-4-like proteins Apaf-1 and ARK, respectively. In an EMS-mutagenesis screen, we isolated 33 ark mutants as recessive suppressors of hid-induced apoptosis. The ark mutants are loss-of-function alleles characterized by reduced developmental apoptosis. Using the phenotypic series of these alleles, we identified helical domain I in the nucleotide oligomerization domain as critical for ARK's apoptotic activity. Interestingly, the WD40 region may also have an unanticipated positive requirement for the apoptotic activity of ARK. Considering structural information, we discuss the roles of these domains for assembly and activity of the ARK apoptosome, and propose that the WD40 region is anti-apoptotic in the absence of apoptotic signals, and pro-apoptotic in the presence of such signals. Furthermore, a defined null allele reveals that ark is required for most, but not all apoptosis suggesting the existence of an ARK-independent apoptotic pathway.

ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity. Publishing Authors By Initials

M Srivastava,H Scherr,M Lackey,D Xu,Z Chen,J Lu,A Bergmann,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation: protein structure, tertiary research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation: protein structure, tertiary research

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ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell death and differentiation

VOLUME: 14

Page Numbers: 92-102

Journal Abbreviation: Cell Death Differ.

ISSN: 1350-9047

DAY: 28

MONTH: 04

YEAR: 2006

ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9437445

ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity. Keywords Mesh Terms:

KEYWORDS: Protein Structure, Tertiary

MESH TERMS: metabolism

Chemical & Substance for Abstract: ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity. Information

Substance Name: Ethyl Methanesulfonate

Registry Number: 62-50-0

Grant and Affiliation Information for ARK, the Apaf-1 related killer in Drosophila, requires diverse domains for its apoptotic activity.

AFFILIATION: Department of Biochemistry and Molecular Biology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

Country: England

AGENCY: United States NIGMS

GRANT: GM068016

ACRONYM: GM

MEDLINETA: Cell Death Differ

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