Arginine vasopressin is an ideal drug after cardiac surgery for the management of low systemic vascular resistant hypotension concomitant with pulmonary hypertension.

Arginine vasopressin is an ideal drug after cardiac surgery for the management of low systemic vascular resistant hypotension concomitant with pulmonary hypertension. Research Abstract Details 

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Arginine vasopressin is an ideal drug after cardiac surgery for the management of low systemic vascular resistant hypotension concomitant with pulmonary hypertension. Abstract Text:

Eiki Tayama,Tomohiro Ueda,Takahiro Shojima,Koji Akasu,Takeshi Oda,Shuji Fukunaga,Hidetoshi Akashi,Shigeaki Aoyagi,Eiki Tayama,Tomohiro Ueda,Takahiro Shojima,Koji Akasu,Takeshi Oda,Shuji Fukunaga,Hidetoshi Akashi,Shigeaki Aoyagi,

Low systemic vascular resistance (SVR) hypotension concomitant with pulmonary hypertension (PH) is difficult to manage postoperatively because they are often catecholamine-resistant. So, we applied arginine vasopressin (AVP), which is a potent vasoconstrictor in a specific condition, for post-cardiotomy refractory low SVR hypotension concomitant with PH. We treated nine cases of postoperative refractory vasodilatory hypotension concomitant with PH even after conventional treatment that included nitric oxide inhalation and/or intraaortic balloon pump. AVP was administrated with 0.05 approximately 0.1 U/min intravenously. After AVP administration, the mean systemic arterial pressure increased from 47.3+/-9.5 to 76.5+/-12.2 mmHg (P<0.01) and SVR increased from 488.1+/-92.7 to 1188+/-87 dynes x s x cm(-5) (P<0.01). Fortunately, even though the cardiac index decreased, it remained in a normal range. Alteration in the PVR was not significant, but the Pp/Ps became somewhat lower (0.66+/-0.2 to 0.47+/-0.16, P<0.01). AVP increased the urine output and improved oxygenation. AVP improved systemic circulation (increased systemic blood pressure with maintaining cardiac output) without deterioration of pulmonary hypertension. AVP is an ideal drug for treating refractory low SVR hypotension concomitant with PH. But its indication must be limited.

Arginine vasopressin is an ideal drug after cardiac surgery for the management of low systemic vascular resistant hypotension concomitant with pulmonary hypertension. Publishing Authors By Initials

E Tayama,T Ueda,T Shojima,K Akasu,T Oda,S Fukunaga,H Akashi,S Aoyagi,E Tayama,T Ueda,T Shojima,K Akasu,T Oda,S Fukunaga,H Akashi,S Aoyagi,

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Arginine vasopressin is an ideal drug after cardiac surgery for the management of low systemic vascular resistant hypotension concomitant with pulmonary hypertension. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Interactive cardiovascular and thoracic surgery

VOLUME: 6

Page Numbers: 715-9

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ISSN: 1569-9285

DAY: 17

MONTH: 08

YEAR: 2007

Arginine vasopressin is an ideal drug after cardiac surgery for the management of low systemic vascular resistant hypotension concomitant with pulmonary hypertension. Information

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LANGUAGE: eng

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AFFILIATION: Department of Surgery, Kurume University Hospital, 67 Asahi-machi, Kurume City, 830-0011, Japan. eiki@med.kurume-u.ac.jp

Country: England

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MEDLINETA: Interact Cardiovasc Thorac Sur

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