Are promyelocytic leukaemia protein nuclear bodies a scaffold for caspase-2 programmed cell death?

Are promyelocytic leukaemia protein nuclear bodies a scaffold for caspase-2 programmed cell death? Research Abstract Details 

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Are promyelocytic leukaemia protein nuclear bodies a scaffold for caspase-2 programmed cell death? Abstract Text:

Luis Sanchez-Pulido,Alfonso Valencia,Ana M Rojas,

Promyelocytic leukaemia protein nuclear bodies (PML-NBs) are nuclear structures whose function is still poorly understood. They are implicated in various biological functions, such as viral infection, cellular transformation, innate immunity and growth control, and they might be dynamic hubs sensing stress and DNA damage. Data from PML(-/-) mice suggest that PML-NBs are involved in apoptosis via caspase-independent mechanisms, probably involving p53-dependent and independent pathways. However, the recently demonstrated co-localization of caspase-2 within the PML-NB nuclear structures presents a new paradigm for nuclear cell death. Here, we show that these nuclear structures have a protein known as SP100 that could contain a caspase recruitment domain (CARD). If verified experimentally, this discovery will suggest a mechanism by which caspase-2 could be recruited into the complex and ultimately lead to apoptosis.

Are promyelocytic leukaemia protein nuclear bodies a scaffold for caspase-2 programmed cell death? Publishing Authors By Initials

L Sanchez-Pulido,A Valencia,AM Rojas,

For similar proteins: neoplasm proteins: tumor suppressor proteins research abstracts see: proteins: neoplasm proteins: tumor suppressor proteins research

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Are promyelocytic leukaemia protein nuclear bodies a scaffold for caspase-2 programmed cell death? Journal Published:

PUBLICATION TYPE: Review

Journal: Trends in biochemical sciences

VOLUME: 32

Page Numbers: 400-6

Journal Abbreviation: Trends Biochem. Sci.

ISSN: 0968-0004

DAY: 10

MONTH: 08

YEAR: 2007

Are promyelocytic leukaemia protein nuclear bodies a scaffold for caspase-2 programmed cell death? Information

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LANGUAGE: eng

NlmUniqueID: 7610674

Are promyelocytic leukaemia protein nuclear bodies a scaffold for caspase-2 programmed cell death? Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Are promyelocytic leukaemia protein nuclear bodies a scaffold for caspase-2 programmed cell death? Information

Substance Name: Cysteine Endopeptidases

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Are promyelocytic leukaemia protein nuclear bodies a scaffold for caspase-2 programmed cell death?

AFFILIATION: National Center for Biotechnology, Consejo Superior de Investigaciones Cientificas. C/Darwin n3, 28049, Madrid, Spain.

Country: England

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MEDLINETA: Trends Biochem Sci

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