Aqueous N,N-diethylnicotinamide (DENA) solution as a medium for accelerated release study of paclitaxel.

Aqueous N,N-diethylnicotinamide (DENA) solution as a medium for accelerated release study of paclitaxel. Research Abstract Details 

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Aqueous N,N-diethylnicotinamide (DENA) solution as a medium for accelerated release study of paclitaxel. Abstract Text:

Namjin Baek,Jaehwi Lee,Kinam Park,

N,N-Diethylnicotinamide (DENA) was identified as an excellent hydrotropic agent for paclitaxel (PTX) in our previous studies. The aqueous solubility of PTX was increased by several orders of magnitude in the presence of DENA. Because of such a high hydrotropic property, DENA was used as a release medium providing a sink condition for the release of PTX from poly(lactic-co-glycolic acid) (PLGA) matrices. The release profiles of PTX from PLGA matrices into DENA, serum and phosphate-buffered saline (PBS) were compared. The stability of PTX in DENA and the degradation of PLGA molecules in DENA were examined. The degradation rate constant of PTX in 2 M DENA was similar to those in other aqueous solutions. The use of 2 M DENA as a release medium allowed differentiation of the release profiles of PTX from PLGA matrices made of different PLGA compositions. The PTX release from PLGA matrices was much faster in DENA solution than in serum or PBS, and the concentration of DENA affected the PTX release rate. The presence of DENA in the release medium increased the hydrolysis rate of PLGA polymers. The faster release of PTX from PLGA matrices in DENA solution may be due to the high PTX solubility and faster degradation of PLGA polymers in the presence of DENA. Our study suggests that the aqueous DENA solution can be used for the accelerated release study of PTX from PLGA matrices.

Aqueous N,N-diethylnicotinamide (DENA) solution as a medium for accelerated release study of paclitaxel. Publishing Authors By Initials

N Baek,J Lee,K Park,

For similar pharmaceutical preparations: solutions research abstracts see: pharmaceutical preparations: solutions research

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Aqueous N,N-diethylnicotinamide (DENA) solution as a medium for accelerated release study of paclitaxel. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 15

Page Numbers: 527-42

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 2004

Aqueous N,N-diethylnicotinamide (DENA) solution as a medium for accelerated release study of paclitaxel. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007393

Aqueous N,N-diethylnicotinamide (DENA) solution as a medium for accelerated release study of paclitaxel. Keywords Mesh Terms:

KEYWORDS: Solutions

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Aqueous N,N-diethylnicotinamide (DENA) solution as a medium for accelerated release study of paclitaxel. Information

Substance Name: Nikethamide

Registry Number: 59-26-7

Grant and Affiliation Information for Aqueous N,N-diethylnicotinamide (DENA) solution as a medium for accelerated release study of paclitaxel.

AFFILIATION: Department of Pharmaceutics and Biomedical Engineering, Purdue University School of Pharmacy, Room G22, 575 Stadium Mall Drive, West Lafayette, IN 47907-2051, USA.

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM 65284

ACRONYM: GM

MEDLINETA: J Biomater Sci Polym Ed

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