Application of three scattering models to characterization of solid tumors in mice.

Application of three scattering models to characterization of solid tumors in mice. Research Abstract Details 

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Application of three scattering models to characterization of solid tumors in mice. Abstract Text:

Michael L Oelze,William D O'Brien,

Two mouse models of mammary cancer (a carcinoma and sarcoma) were examined using quantitative ultrasound (QUS) and three models for ultrasound backscattering. The first model that was examined was the spherical Gaussian model (SGM). The second model was the fluid-filled sphere model (FFSM) and was hypothesized to model scattering from cell nuclei with the cell cytoplasm acting as background. The third model, called the new cell model (NCM), was constructed to model backscattering from cell nuclei and cytoskeleton. The average scatterer diameters (ASDs) were estimated from regions-of-interest (ROIs) inside the tumors using all three models and then compared. The ultrasound analysis bandwidth used in the study was 16 to 27 MHz. QUS images of the tumors utilizing the ASD estimates from the three models were constructed. The ASDs were 30.3 +/- 3.06 microm and 25.2 +/- 4.01 microm with the SGM, 47.3 +/- 7.99 microm and 47.7 +/- 7.01 microm with the FFSM and 41.2 +/- 1.39 microm and 34.4 +/- 5.95 microm with the NCM for the carcinoma and sarcoma, respectively, statistically significant differences between the ASD estimates from the carcinomas and sarcomas were observed using the SGM and NCM but not with the FFSM.

Application of three scattering models to characterization of solid tumors in mice. Publishing Authors By Initials

ML Oelze,WD O'Brien,

For similar natural sciences: physics: acoustics: ultrasonics research abstracts see: natural sciences: physics: acoustics: ultrasonics research

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Application of three scattering models to characterization of solid tumors in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Ultrasonic imaging

VOLUME: 28

Page Numbers: 83-96

Journal Abbreviation:

ISSN: 0161-7346

DAY: 3

MONTH: Apr

YEAR: 2006

Application of three scattering models to characterization of solid tumors in mice. Information

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LANGUAGE: eng

NlmUniqueID: 7909167

Application of three scattering models to characterization of solid tumors in mice. Keywords Mesh Terms:

KEYWORDS: Ultrasonics

MESH TERMS: ultrasonography

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Grant and Affiliation Information for Application of three scattering models to characterization of solid tumors in mice.

AFFILIATION: Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 405 North Mathews, Urbana, Illinois 61801, USA. oelze@uiuc.edu

Country: United States

AGENCY: United States NCI

GRANT: F32 CA96419

ACRONYM: CA

MEDLINETA: Ultrason Imaging

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