Application of the intramolecular Yamamoto vinylogous aldol reaction to the synthesis of macrolides.

Application of the intramolecular Yamamoto vinylogous aldol reaction to the synthesis of macrolides. Research Abstract Details 

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Application of the intramolecular Yamamoto vinylogous aldol reaction to the synthesis of macrolides. Abstract Text:

Joseph A Abramite,Tarek Sammakia,

An intramolecular version of the Yamamoto vinylogous aldol reaction, a method that employs the bulky Lewis acid ATPH to control the site of aldolization, is described. This macrocyclization process is effective for the construction of 10-, 12-, and 14-membered macrolides. The yields are high (70-90%), and the reaction can proceed with excellent remote stereocontrol (dr > or = 20:1) with chiral substrates.

Application of the intramolecular Yamamoto vinylogous aldol reaction to the synthesis of macrolides. Publishing Authors By Initials

JA Abramite,T Sammakia,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure research

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Application of the intramolecular Yamamoto vinylogous aldol reaction to the synthesis of macrolides. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Organic letters

VOLUME: 9

Page Numbers: 2103-6

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 25

MONTH: 04

YEAR: 2007

Application of the intramolecular Yamamoto vinylogous aldol reaction to the synthesis of macrolides. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100890393

Application of the intramolecular Yamamoto vinylogous aldol reaction to the synthesis of macrolides. Keywords Mesh Terms:

KEYWORDS: Molecular Structure

MESH TERMS: chemical synthesis

Chemical & Substance for Abstract: Application of the intramolecular Yamamoto vinylogous aldol reaction to the synthesis of macrolides. Information

Substance Name: Macrolides

Registry Number: 0

Grant and Affiliation Information for Application of the intramolecular Yamamoto vinylogous aldol reaction to the synthesis of macrolides.

AFFILIATION: Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM48498

ACRONYM: GM

MEDLINETA: Org Lett

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