Application of instrumental evaluation of color for the pre-formulation and formulation of rabeprazole.

Application of instrumental evaluation of color for the pre-formulation and formulation of rabeprazole. Research Abstract Details 

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Application of instrumental evaluation of color for the pre-formulation and formulation of rabeprazole. Abstract Text:

Yun-Seok Rhee,Chun-Woong Park,Yoon-Sub Shin,Sung-Hoon Kam,Kyu-Hyun Lee,Eun-Seok Park,

The aims of this study were to fast screen the compatibility of rabeprazole and excipients using a spectrocolorimeter and to examine the relationship between the color change value and drug contents/drug degradation products in solid dosage forms. The color change values of rabeprazole-excipient mixtures were measured using a spectrocolorimeter, with six tablet formulations compressed using a single-punch instrumental tablet press. The rabeprazole and degradation products contents in the tablets were analyzed using an HPLC method, with the color change values of the tablets measured using spectrocolorimetery for 4 weeks. These experiments indicated that the instrumental evaluation of color was a speedy, simple and useful tool in the determination of the interaction between the drug and excipients, as well as in the formulation of solid dosage forms. The relationships of the % reduced drug contents versus the color change value, and those of the % drug degradation products versus the color change value were exponentially increased in formulations containing zinc stearate. On stress testing, the color change value of rabeprazole was inconsistent with previous reports, as the degradation of rabeprazole can be greatly influenced by humidity as well as temperature. Consequently, these results highlight the potential of color formation in the application of pre-formulation and formulation of drugs.

Application of instrumental evaluation of color for the pre-formulation and formulation of rabeprazole. Publishing Authors By Initials

YS Rhee,CW Park,YS Shin,SH Kam,KH Lee,ES Park,

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Application of instrumental evaluation of color for the pre-formulation and formulation of rabeprazole. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of pharmaceutics

VOLUME: 350

Page Numbers: 122-9

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ISSN: 0378-5173

DAY: 31

MONTH: 08

YEAR: 2007

Application of instrumental evaluation of color for the pre-formulation and formulation of rabeprazole. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Application of instrumental evaluation of color for the pre-formulation and formulation of rabeprazole.

AFFILIATION: College of Pharmacy, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon, Gyeonggi-do 440-746, Republic of Korea.

Country: Netherlands

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MEDLINETA: Int J Pharm

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