Appendectomy in familial Mediterranean fever: clinical, genetic and pathological findings.

Appendectomy in familial Mediterranean fever: clinical, genetic and pathological findings. Research Abstract Details 

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Appendectomy in familial Mediterranean fever: clinical, genetic and pathological findings. Abstract Text:

BACKGROUND:Abdominal attacks of familial Mediterranean fever (FMF) may simulate acute appendicitis and bring about considerable uncertainty. The similar presentation of the two clinical entities often leads to an unnecessary appendectomy.METHODS:182 consecutive FMF patients were retrospectively reviewed for this study. Clinical and genetic data was compared between those who had undergone an appendectomy (n=71) and those who had not (n=111). RESULTS:The frequency of appendectomy found in FMF was far above the reported rate in the general population (40% vs. 12-25%). The rate of non-inflamed appendectomies was extremely high (80% vs. 20%) and remained constant over time. Tertiary hospitals and improved therapeutic and diagnostic measures that have evolved over the years did not reduce misdiagnosis of acute appendicitis in FMF. Severe phenotype and homozygosity for M694V were identified as risk factors for appendectomy in FMF. A change from the regular diffuse involvement to right lower quadrant abdominal pain was found to be the best predictor of inflamed appendix in FMF patients undergoing appendectomy for suspected acute appendicitis. CONCLUSION:Reliance on clinical parameters should improve diagnostic accuracy of acute appendicitis in the FMF patient population.

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MEDLINE DATE: 2008 Jul-Aug

Appendectomy in familial Mediterranean fever: clinical, genetic and pathological findings. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental rheumatology

VOLUME: 26

Page Numbers: 568-73

Journal Abbreviation: Clin. Exp. Rheumatol.

ISSN: 0392-856X

DAY: 18

MONTH: 09

YEAR: 2008

Appendectomy in familial Mediterranean fever: clinical, genetic and pathological findings. Information

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LANGUAGE: eng

NlmUniqueID: 8308521

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Grant and Affiliation Information for Appendectomy in familial Mediterranean fever: clinical, genetic and pathological findings.

AFFILIATION: 1Heller Institute of Medical Research, Sheba Medical Center, Tel-Hashomer, affiliated with the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Country: Italy

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MEDLINETA: Clin Exp Rheumatol

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