Appearance of B220 autoantibody-producing B-1 cells at neonatal and older stages in mice.

Appearance of B220 autoantibody-producing B-1 cells at neonatal and older stages in mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Appearance of B220 autoantibody-producing B-1 cells at neonatal and older stages in mice. Abstract Text:

In this study, normal adult mice carried B220(high) conventional B cells in the spleen and liver, but carried both B220(high) and B220(low) in the bone marrow. However, at the neonatal stage, only B220(low) unconventional B cells were found in all these organs. This pattern continued up to 2 weeks after birth, and at this stage autoantibodies were detected in the sera. This phenomenon was seen in all tested young mice (1-2 weeks), irrespective of their gender. Furthermore, at older stages (more than 20 weeks), B220(low) cells reappeared in the spleen and liver, and these B220(low) cells became dominant in the bone marrow. Autoantibodies also reappeared in the sera of these older mice. Cell-sorting experiments revealed that B220(low) cells were able to produce autoantibodies upon lipopolysaccharide stimuli in vitro. These results suggest that B220(low) cells appear at both neonatal and older stages as physiological responses and eventually produce autoantibodies.

Appearance of B220 autoantibody-producing B-1 cells at neonatal and older stages in mice. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Appearance of B220 autoantibody-producing B-1 cells at neonatal and older stages in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental immunology

VOLUME: 153

Page Numbers: 448-55

Journal Abbreviation: Clin. Exp. Immunol.

ISSN: 1365-2249

DAY: 18

MONTH: 07

YEAR: 2008

Appearance of B220 autoantibody-producing B-1 cells at neonatal and older stages in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 57202

Appearance of B220 autoantibody-producing B-1 cells at neonatal and older stages in mice. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Appearance of B220 autoantibody-producing B-1 cells at neonatal and older stages in mice. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Appearance of B220 autoantibody-producing B-1 cells at neonatal and older stages in mice.

AFFILIATION: Department of Immunology, Niigata University School of Medicine, Niigata, Japan.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Exp Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Appearance of B220 autoantibody-producing B-1 cells at neonatal and older stages in mice Related Publications

• Activation of the prefrontal cortex during the wisconsin card sorting test (Keio Version) as measured by two-channel near-infrared spectroscopy in patients with traumatic brain injury.
• Appearance of B220 autoantibody-producing B-1 cells at neonatal and older stages in mice.
• Identification and functional reconstitution of effector proteins for the GTPases Rac and CDC42Hs.
• Malaria protection in beta 2-microglobulin-deficient mice lacking major histocompatibility complex class I antigens: essential role of innate immunity, including gammadelta T cells.
• Multipotential acceptance of Peyer's patches in the intestine for both thymus-derived T cells and extrathymic T cells in mice.
• R-spondin family members regulate the wnt pathway by a common mechanism.
• Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice.
• Role of alpha-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity.
• [A case report of the pure red cell aplasia with thymoma (author's transl)]
• [General and biological factors in acute postoperative eventration.]
• [The goal in clinical training in psychiatric nursing and the evaluation of the learning format]