Apparent diffusion coefficient value of the hippocampus in patients with hippocampal sclerosis and in healthy volunteers.

Apparent diffusion coefficient value of the hippocampus in patients with hippocampal sclerosis and in healthy volunteers. Research Abstract Details 

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Apparent diffusion coefficient value of the hippocampus in patients with hippocampal sclerosis and in healthy volunteers. Abstract Text:

So Young Yoo,Kee-Hyun Chang,In Chan Song,Moon Hee Han,Bae Ju Kwon,Sang Hyun Lee,In Kyu Yu,Chun-Kee Chun,

BACKGROUND AND PURPOSE: MR diffusion-weighted (DW) imaging with apparent diffusion coefficient (ADC) has had widespread use clinically in a variety of intracranial diseases; however, only a few studies report ADC changes in patients with hippocampal sclerosis. We sought to determine the ability of ADC to lateralize the epileptogenic lesion in patients with hippocampal sclerosis. METHODS: Nineteen healthy volunteers and 18 patients with intractable temporal lobe epilepsy whose MR imaging diagnosis was unilateral hippocampal sclerosis were examined prospectively with DW imaging and ADC mapping. DW images were obtained at 1.5 T with a spin-echo echo-planar sequence (6500/103 [TR/TE]) with variable diffusion gradients. ADCs were calculated from bilateral hippocampi. The ability of DW imaging and ADC to lateralize the lesion was evaluated visually and by comparing ADC values between healthy volunteers and patients with hippocampal sclerosis. RESULTS: In all patients, visual assessment of DW images failed to lateralize the lesion. However, the mean ADC value measured at the hippocampal area was significantly higher on the lesion side than on the contralateral side (P <.001). The overall correct lateralization rate of ADC was 100% (18 of 18 patients). Mean ADC in sclerotic hippocampi was also significantly higher than that in healthy volunteers. The normal-appearing hippocampus of the contralateral side in the patients had higher ADC values compared with those of healthy volunteers (P =.045). CONCLUSION: ADC can be used as a complementary tool in lateralizing the epileptogenic lesion in patients with hippocampal sclerosis, although the practical role of ADC value is yet to be determined in patients with inconclusive MR imaging findings.

Apparent diffusion coefficient value of the hippocampus in patients with hippocampal sclerosis and in healthy volunteers. Publishing Authors By Initials

SY Yoo,KH Chang,IC Song,MH Han,BJ Kwon,SH Lee,IK Yu,CK Chun,

For similar pathological conditions, signs and symptoms: pathologic processes: sclerosis research abstracts see: pathological conditions, signs and symptoms: pathologic processes: sclerosis research

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Apparent diffusion coefficient value of the hippocampus in patients with hippocampal sclerosis and in healthy volunteers. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: AJNR. American journal of neuroradiology

VOLUME: 23

Page Numbers: 809-12

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ISSN: 0195-6108

DAY: 14

MONTH: May

YEAR: 2002

Apparent diffusion coefficient value of the hippocampus in patients with hippocampal sclerosis and in healthy volunteers. Information

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LANGUAGE: eng

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Apparent diffusion coefficient value of the hippocampus in patients with hippocampal sclerosis and in healthy volunteers. Keywords Mesh Terms:

KEYWORDS: Sclerosis

MESH TERMS: methods

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Grant and Affiliation Information for Apparent diffusion coefficient value of the hippocampus in patients with hippocampal sclerosis and in healthy volunteers.

AFFILIATION: Department of Radiology, Seoul National University College of Medicine, Korea.

Country: United States

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MEDLINETA: AJNR Am J Neuroradiol

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