Apoptotic and survival signals in hepatic stellate cells.

Apoptotic and survival signals in hepatic stellate cells. Research Abstract Details

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Apoptotic and survival signals in hepatic stellate cells. Abstract Text:

Hong Shen,Jianghong Fan,Gerald Minuk,Yuewen Gong,Hong Shen,Jianghong Fan,Gerald Minuk,Yuewen Gong,

Hepatic stellate cells (HSCs) play an important role in hepatic fibrogenesis. In response to liver injury, HSCs undergo a process called activation, which involves 2 stepsjinitiation from quiescent phenotype to myofibroblast-like phenotype, and perpetuation that maintains the activated phenotype of HSCs. The fate of the activated HSCs depends on the apoptotic and survival signals that they receive. The apoptosis of HSCs results from a series of complex and interrelated signaling events. Apoptotic signals for the activated HSCs include proteins from membrane receptors, such as death receptors, nerve growth factor receptor and peripheral-type benzodiazepine receptor, as well as proteins from cytoplasm such as Bcl-2 family members. The survival signals for the activated HSCs are induced by some kinases and cytokines including tissue inhibitors of metalloproteinase-1, Rho/Rho kinase, platelet-derived growth factor, transforming growth factor beta-1, and insulin-like growth factor-1. Approaches that specifically initiate HSC apoptosis are promising to be direct and effective strategies to treat liver fibrosis. Although it remains unclear whether the activated HSCs could be reversed back to the quiescent phenotype, the different expression and sensitivity of pro-apoptotic and survival molecules between quiescent and activated HSCs provide a prospect to develop therapeutic approaches that specifically targets apoptosis of the activated HSCs. These therapeutic strategies to induce HSC apoptosis are current research hotspot and the future for the patients with liver fibrosis and cirrhosis.

Apoptotic and survival signals in hepatic stellate cells. Publishing Authors By Initials

H Shen,J Fan,G Minuk,Y Gong,H Shen,J Fan,G Minuk,Y Gong,

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Apoptotic and survival signals in hepatic stellate cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of

VOLUME: 32

Page Numbers: 726-34

Journal Abbreviation: Zhong Nan Da Xue Xue Bao Yi Xu

ISSN: 1672-7347

DAY: 16

MONTH: Oct

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 101230586

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AFFILIATION: Faculty of Pharmacy; Section of Liver Diseases, Health Sciences Center, College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

Country: China