Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death.

Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Research Abstract Details 

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Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Abstract Text:

Seong-Woon Yu,Shaida A Andrabi,Hongmin Wang,No Soo Kim,Guy G Poirier,Ted M Dawson,Valina L Dawson,

Apoptosis-inducing factor (AIF), a mitochondrial oxidoreductase, is released into the cytoplasm to induce cell death in response to poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation. How PARP-1 activation leads to AIF release is not known. Here we identify PAR polymer as a cell death signal that induces release of AIF. PAR polymer induces mitochondrial AIF release and translocation to the nucleus. PAR glycohydrolase, which degrades PAR polymer, prevents PARP-1-dependent AIF release. Cells with reduced levels of AIF are resistant to PARP-1-dependent cell death and PAR polymer cytotoxicity. These results reveal PAR polymer as an AIF-releasing factor that plays important roles in PARP-1-dependent cell death.

Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Publishing Authors By Initials

SW Yu,SA Andrabi,H Wang,NS Kim,GG Poirier,TM Dawson,VL Dawson,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: biological transport: protein transport research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: biological transport: protein transport research

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Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 103

Page Numbers: 18314-9

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 20

MONTH: 11

YEAR: 2006

Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Keywords Mesh Terms:

KEYWORDS: Protein Transport

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Information

Substance Name: Poly Adenosine Diphosphate Ribose

Registry Number: 26656-46-2

Grant and Affiliation Information for Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death.

AFFILIATION: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS39148

ACRONYM: NS

MEDLINETA: Proc Natl Acad Sci U S A

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