Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro.

Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro. Research Abstract Details 

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Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro. Abstract Text:

S C Welburn,C Dale,D Ellis,R Beecroft,T W Pearson,

Apoptosis is a phenomenon previously associated exclusively with metazoan organisms. We show here that procyclic insect form Trypanosoma brucei rhodesiense, a protozoan parasite, when treated in vitro with concanavalin A displayed several features normally associated with apoptosis in metazoan cells. Lectin treatment induced cleavage of nuclear DNA into oligonucleosomal fragments, suggesting activation of an endogenous nuclease in the parasite. Treated trypanosomes, although agglutinated and non-motile, exhibited fluorescence after treatment with the vital stain fluorescein diacetate and retained (3)H-uridine indicating that their cell membranes remained intact during the period of DNA fragmentation. Electron micrographs showed characteristic morphology of cells undergoing apoptosis, including surface membrane vesiculation and migration of chromatin to the periphery of the nuclear membrane while mitochondria remained intact. These results suggest that treatment with concanavalin A triggers a cell death mechanism in T. b. rhodesiense similar to the process of apoptosis described in metazoa.

Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro. Publishing Authors By Initials

SC Welburn,C Dale,D Ellis,R Beecroft,TW Pearson,

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Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell death and differentiation

VOLUME: 3

Page Numbers: 229-36

Journal Abbreviation: Cell Death Differ.

ISSN: 1350-9047

DAY: 20

MONTH: Apr

YEAR: 1996

Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro. Information

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LANGUAGE: eng

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AFFILIATION: Tsetse Research Group, Division of Molecular Genetics, IBLS, University of Glasgow, Anderson College, 56 Dumbarton Road, Glasgow G11 6NU, UK.

Country: England

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MEDLINETA: Cell Death Differ

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