Apoptosis and autoimmunity.

Apoptosis and autoimmunity. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Apoptosis and autoimmunity. Abstract Text:

Jeannine S Navratil,Chau-Ching Liu,Joseph M Ahearn,

Cell death by apoptosis plays a significant and seemingly contradictory role in the development and pathogenesis of autoimmune diseases. Apoptosis is integral to the assembly and maintenance of a healthy, self-tolerant immune system. However, many of the molecular and cellular events specific to apoptosis generate a reservoir of self-antigens with the potential to initiate and possibly perpetuate autoimmune conditions. Recent findings that support this latter, more sinister role for apoptosis have shed light on a mystery that is common to many systemic autoimmune diseases, namely, why the majority of autoantibodies produced in patients with these diseases target proteins that are normally found inside the cell, often within the nucleus. This review will discuss how autoantigens are specifically altered during the apoptotic process, and how the complement system participates in recognizing and clearing these potentially immunogenic packages.

Apoptosis and autoimmunity. Publishing Authors By Initials

JS Navratil,CC Liu,JM Ahearn,

For similar biological phenomena, cell phenomena, and immunity: immunity: immune tolerance research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: immune tolerance research

PUBMED ID PMID:

MEDLINE DATE:

Apoptosis and autoimmunity. Journal Published:

PUBLICATION TYPE: Review

Journal: Immunologic research

VOLUME: 36

Page Numbers: 3-12

Journal Abbreviation: Immunol. Res.

ISSN: 0257-277X

DAY: 3

MONTH: 12

YEAR: 2006

Apoptosis and autoimmunity. Information

Number of References: 84

LANGUAGE: eng

NlmUniqueID: 8611087

Apoptosis and autoimmunity. Keywords Mesh Terms:

KEYWORDS: Immune Tolerance

MESH TERMS: immunology

Chemical & Substance for Abstract: Apoptosis and autoimmunity. Information

Substance Name: Autoantigens

Registry Number: 0

Grant and Affiliation Information for Apoptosis and autoimmunity.

AFFILIATION: Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: AR-4676402

ACRONYM: AR

MEDLINETA: Immunol Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Apoptosis and autoimmunity Related Publications

• A comparison of momentary time sampling and partial-interval recording for evaluating functional relations.
• Apoptosis and autoimmunity.
• Caring made a difference.
• Cell-bound complement activation products (CB-CAPs) as a source of lupus biomarkers.
• Experimental system for ex vivo measurement of murine aortic stiffness.
• Heavy metal detoxification in crustacean epithelial lysosomes: role of anions in the compartmentalization process.
• Management of severe postlumbar puncture headache.
• Mannose-binding lectin is a disease-modifying factor in North American patients with systemic lupus erythematosus.
• Transepithelial transport of zinc and L-histidine across perfused intestine of American lobster, Homarus americanus.
• [Admissions to psychiatric services following a natural disaster]