Apolipoprotein E epsilon4 offers protection against age-related macular degeneration.

Apolipoprotein E epsilon4 offers protection against age-related macular degeneration. Research Abstract Details 

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Apolipoprotein E epsilon4 offers protection against age-related macular degeneration. Abstract Text:

Duncan A Friedman,Walter J Lukiw,James M Hill,

BACKGROUND: In many previous studies, age-related macular degeneration (ARMD) has been linked to a variety of different risk factors. The publications have debated whether apolipoprotein E (apoE) epsilon4 serves as a potential protective factor in the development of the disease. Other studies have classified the behavior of this protein in different pathologies, including Alzheimer's disease (AD) and cardiovascular disease. The general behavior of the epsilon4 isoform of ApoE is different than the predominant epsilon3 isoform. HYPOTHESIS: We propose that the general characteristics and molecular behavior of apoE epsilon4 cause it to be a protective factor against the development of ARMD by preventing cumulative effects of oxidative retinal damage. EVALUATION OF HYPOTHESIS: Review of the literature related to ARMD and ApoE, using OVID as our main database, led to the development of several theories regarding ApoE epsilon4's behavior compared to epsilon3 and potential explanation of its protective characteristics. CONSEQUENCES OF HYPOTHESIS: We relate these theories to the potential behavior of ApoE epsilon4 in other situations including choroidal neovascularization, Alzheimer's Disease (AD), cardiovascular disease, herpes simplex virus infection, and smoking. DISCUSSION: The potential implications of this theory could be used as a branching point for further studies that examine the role of the different apoE isoforms, in relation to the other risk factors for ARMD.

Apolipoprotein E epsilon4 offers protection against age-related macular degeneration. Publishing Authors By Initials

DA Friedman,WJ Lukiw,JM Hill,

For similar chemical actions and uses: pharmacologic actions: physiological effects of drugs: protective agents research abstracts see: chemical actions and uses: pharmacologic actions: physiological effects of drugs: protective agents research

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Apolipoprotein E epsilon4 offers protection against age-related macular degeneration. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Medical hypotheses

VOLUME: 68

Page Numbers: 1047-55

Journal Abbreviation: Med. Hypotheses

ISSN: 0306-9877

DAY: 4

MONTH: 12

YEAR: 2006

Apolipoprotein E epsilon4 offers protection against age-related macular degeneration. Information

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LANGUAGE: eng

NlmUniqueID: 7505668

Apolipoprotein E epsilon4 offers protection against age-related macular degeneration. Keywords Mesh Terms:

KEYWORDS: Protective Agents

MESH TERMS: metabolism

Chemical & Substance for Abstract: Apolipoprotein E epsilon4 offers protection against age-related macular degeneration. Information

Substance Name: Protective Agents

Registry Number: 0

Grant and Affiliation Information for Apolipoprotein E epsilon4 offers protection against age-related macular degeneration.

AFFILIATION: Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA 70112-2234, United States.

Country: Scotland

AGENCY: United States NEI

GRANT: R01 EY006311-21

ACRONYM: EY

MEDLINETA: Med Hypotheses

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