Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia.

Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia. Research Abstract Details 

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Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia. Abstract Text:

T Rodriguez Martin,A M Calella,S Silva,E Munna,P Modena,R Chiesa,S Terrevazzi,R M Ruggieri,R Palermo,F Piccoli,R Confalonieri,P Tiraboschi,C Fragiacomo,P Quadri,U Lucca,G Forloni,

Apolipoprotein E (ApoE) genotypes, presenilin 1 (PS-1) and alpha(1)-antichymotrypsin (ACT) polymorphism and the association of the genotypes were examined in patients with Alzheimer's disease (AD, n = 121) or vascular dementia (VD, n = 68) in comparison with elderly controls (n = 125). The frequency of the ApoE epsilon 4 allele was significantly increased both in late-onset AD (0.35) and in VD (0.17); the frequency of ApoE epsilon 2 was significantly reduced in AD, but it was similar in VD and controls. The presence of the allele 1 of PS-1 intronic polymorphism was not associated with AD or VD and was not influenced by the ApoE genotypes. Also, the frequency of allele A of the intronic polymorphism of ACT was similar in AD, VD and controls and it was not altered by ApoE or PS-1 genotypes. The results confirm the association between ApoE epsilon 4 and AD and indicate an increase in ApoE epsilon 4 in Vd, too. A potential protective role of ApoE epsilon 2 is also suggested for late-onset AD but not for VD. No association was shown between ACT allele A and PS-1 allele 1 in AD or VD.

Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia. Publishing Authors By Initials

T Rodriguez Martin,AM Calella,S Silva,E Munna,P Modena,R Chiesa,S Terrevazzi,RM Ruggieri,R Palermo,F Piccoli,R Confalonieri,P Tiraboschi,C Fragiacomo,P Quadri,U Lucca,G Forloni,

For similar peptides: proteinase inhibitory proteins, secretory: alpha 1-antitrypsin research abstracts see: peptides: proteinase inhibitory proteins, secretory: alpha 1-antitrypsin research

PUBMED ID PMID:

MEDLINE DATE: 2000 Sep-Oct

Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Dementia and geriatric cognitive disorders

VOLUME: 11

Page Numbers: 239-44

Journal Abbreviation: Dement Geriatr Cogn Disord

ISSN: 1420-8008

DAY: 24

MONTH: 03

YEAR: 2008

Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia. Information

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LANGUAGE: eng

NlmUniqueID: 9705200

Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia. Keywords Mesh Terms:

KEYWORDS: alpha 1-Antitrypsin

MESH TERMS: genetics

Chemical & Substance for Abstract: Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia. Information

Substance Name: alpha 1-Antitrypsin

Registry Number: 0

Grant and Affiliation Information for Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia.

AFFILIATION: Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italia.

Country: SWITZERLAND

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MEDLINETA: Dement Geriatr Cogn Disord

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