APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome.

APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome. Abstract Text:

Michael Miller,Jeffrey Rhyne,Hegang Chen,Valerie Beach,Richard Ericson,Kalpana Luthra,Manjari Dwivedi,Anoop Misra,

BACKGROUND: Despite the growing epidemic of the metabolic syndrome (MetS), few studies have evaluated genetic polymorphisms associated with the MetS phenotype. One candidate, APOC3, modulates lipid and lipoprotein metabolism and the promoter polymorphisms C-482T/T-455C are associated with loss of insulin downregulation. METHODS: One hundred twenty two consecutive MetS cases were matched by age, sex and race in a 1:1 case-control design to evaluate the prevalence of common polymorphisms in the following candidate genes: APOC3, APOE, B3AR, FABP2, GNB3, LPL, and PPARalpha and PPARgamma. RESULTS: Compared to controls, MetS subjects exhibited a greater prevalence of APOC3 promoter polymorphisms. Specifically, the frequency of the variant C-482T and T-455C alleles was 70.5 and 81.9% of cases compared to 43.4 and 54.1% in controls, respectively (p <0.0001). Overall, APOC3 promoter variants were associated with a greater likelihood of MetS compared to wild type [C-482T (OR: 4.3; 95% CI: 2.2, 8.6 [p <0.0001]), T-455C (OR: 3.6; 95% CI: 2.0, 6.7 [p <0.0001])]. No material differences were identified between the other genetic variants tested and prevalence of MetS. CONCLUSIONS: These data, therefore, suggest that the APOC3 promoter polymorphisms C-482T and T-455C are associated with the MetS.

APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome. Publishing Authors By Initials

M Miller,J Rhyne,H Chen,V Beach,R Ericson,K Luthra,M Dwivedi,A Misra,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: base sequence: regulatory sequences, nucleic acid: promoter regions (genetics) research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: base sequence: regulatory sequences, nucleic acid: promoter regions (genetics) research

PUBMED ID PMID:

MEDLINE DATE:

APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Archives of medical research

VOLUME: 38

Page Numbers: 444-51

Journal Abbreviation:

ISSN: 0188-4409

DAY: 26

MONTH: 03

YEAR: 2007

APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9312706

APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome. Keywords Mesh Terms:

KEYWORDS: Promoter Regions (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome. Information

Substance Name: Apolipoprotein C-III

Registry Number: 0

Grant and Affiliation Information for APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome.

AFFILIATION: University of Maryland Hospital and Veterans Affairs Medical Center, Baltimore, Maryland, USA. mmiller@medicine.umaryland.edu

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL061369-04

ACRONYM: HL

MEDLINETA: Arch Med Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome Related Publications

• 3,3'-Di-O-methyl ellagic acid-4-O-glucuronosyl-arabinosyl-arabinosyl-glucoside from Prosopis juliflora Pods.
• A New Anthraquinone from Cassia sophera Heartwood.
• A rare case of primary invasive carcinoma of vagina associated with irreducible third degree uterovaginal prolapse.
• A unique congenital mullerian anomaly: Robert's uterus.
• A wireless trust model for healthcare.
• AMP activated protein kinase: a next generation target for total metabolic control.
• APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome.
• Anthraquinones of Cassia marginata Seeds.
• Assembly of LamB and OmpF in deep rough lipopolysaccharide mutants of Escherichia coli K-12.
• Basic calcium phosphate crystals activate c-fos expression through a Ras/ERK dependent signaling mechanism.
• Chemical Features and Productivity of a Geraniol-Rich Variety (GRL-1) of Cymbopogon flexuosus*.
• Comparison of pathogen-induced expression and efficacy of two amphibian antimicrobial peptides, MsrA2 and temporin A, for engineering wide-spectrum disease resistance in tobacco.
• Does using ethnic specific criteria improve the usefulness of the term metabolic syndrome? Controversies and suggestions.
• Editorial commentary.
• Enhancement of apoptosis of THP-1 cells infected with Mycobacterium tuberculosis by inhalable microparticles and relevance to bactericidal activity.
• First Glimpse of the Crystal Structure of YaeT's POTRA Domains.
• Glycyrrhetol and beta-Peltoboykinolic Acid from Adenocalymma alliaceum.
• Initial steps of colicin E1 import across the outer membrane of Escherichia coli.
• Neonatal outcomes after vaginal and caesarean breech delivery.
• New Flavanones from Prosopis juliflora Roots.
• Nose-to-brain delivery of tacrine.
• Pattern of congenital heart disease in King Fahd Specialist Hospital, Buraidah.
• RecBC enzyme overproduction affects UV and gamma radiation survival of Deinococcus radiodurans.
• Risk factors for bacterial vaginosis during pregnancy among African American women.
• Saphenous Vein Graft-to-Left Atrium Fistula Treated with Percutaneous Transcatheter Embolization with Coils.
• Selectivity sequences and sorption capacities of phosphatic clay and humus rich soil towards the heavy metals present in zinc mine tailing.
• Short course of oral prednisolone on disappearance of lesion and seizure recurrence in patients of solitary cysticercal granuloma with single small enhancing CT lesion: an open label randomized prospective study.
• Simulation of slow-motion CW EPR spectrum using stochastic Liouville equation for an electron spin coupled to two nuclei with arbitrary spins: Matrix elements of the Liouville superoperator.
• Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy.
• Toxic effect of arsenate and cadmium alone and in combination on giant duckweed (Spirodela polyrrhiza L.) in response to its accumulation.