Apigenin suppresses cancer cell growth through ERbeta.

Apigenin suppresses cancer cell growth through ERbeta. Research Abstract Details 

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Apigenin suppresses cancer cell growth through ERbeta. Abstract Text:

Paul Mak,Yuet-Kin Leung,Wan-Yee Tang,Charlotte Harwood,Shuk-Mei Ho,

Two flavonoids, genistein and apigenin, have been implicated as chemopreventive agents against prostate and breast cancers. However, the mechanisms behind their respective cancer-protective effects may vary significantly. The goal of this study was to determine whether the antiproliferative action of these flavonoids on prostate (DU-145) and breast (MDA-MB-231) cancer cells expressing only estrogen receptor (ER) beta is mediated by this ER subtype. It was found that both genistein and apigenin, although not 17beta-estradiol, exhibited antiproliferative effects and proapoptotic activities through caspase-3 activation in these two cell lines. In yeast transcription assays, both flavonoids displayed high specificity toward ERbeta transactivation, particularly at lower concentrations. However, in mammalian assay, apigenin was found to be more ERbeta-selective than genistein, which has equal potency in inducing transactivation through ERalpha and ERbeta. Small interfering RNA-mediated downregulation of ERbeta abrogated the antiproliferative effect of apigenin in both cancer cells but did not reverse that of genistein. Our data unveil, for the first time, that the anticancer action of apigenin is mediated, in part, by ERbeta. The differential use of ERalpha and ERbeta signaling for transaction between genistein and apigenin demonstrates the complexity of phytoestrogen action in the context of their anticancer properties.

Apigenin suppresses cancer cell growth through ERbeta. Publishing Authors By Initials

P Mak,YK Leung,WY Tang,C Harwood,SM Ho,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

PUBMED ID PMID:

MEDLINE DATE:

Apigenin suppresses cancer cell growth through ERbeta. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neoplasia (New York, N.Y.)

VOLUME: 8

Page Numbers: 896-904

Journal Abbreviation: Neoplasia

ISSN: 1476-5586

DAY: 3

MONTH: Nov

YEAR: 2006

Apigenin suppresses cancer cell growth through ERbeta. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100886622

Apigenin suppresses cancer cell growth through ERbeta. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: metabolism

Chemical & Substance for Abstract: Apigenin suppresses cancer cell growth through ERbeta. Information

Substance Name: Caspase 3

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Apigenin suppresses cancer cell growth through ERbeta.

AFFILIATION: Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Country: Canada

AGENCY: United States NIEHS

GRANT: ES013071

ACRONYM: ES

MEDLINETA: Neoplasia

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