Apical NA+/H+ exchangers in the mammalian gastrointestinal tract.

Apical NA+/H+ exchangers in the mammalian gastrointestinal tract. Research Abstract Details 

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Apical NA+/H+ exchangers in the mammalian gastrointestinal tract. Abstract Text:

P R Kiela,H Xu,F K Ghishan,P R Kiela,H Xu,F K Ghishan,

The Slc9a family of nine Na(+)/H(+) exchangers (NHE) plays a critical role in neutral sodium absorption in the mammalian intestine as well as other absorptive and secretory epithelia of digestive organs. These transport proteins mediate the electroneutral exchange of Na(+) and H(+) and are crucial in a variety of physiological processes, including the fine tuning of intracellular pH, cell volume control and systemic electrolyte, acid-base and fluid volume homeostasis. Here, we review the role of the Na(+)/H(+) exchange mechanism as it relates to the physiology of organs and cells involved in nutrient absorption, and we describe physiological and molecular aspects of individual isoforms, including their structure, tissue-, and subcellular distribution, as well as their regulation by physiological stimuli at the transcriptional and post-transcriptional levels. A particular emphasis is placed on Na(+)/H(+) exchanger isoforms expressed on the apical (brush border) membrane of the epithelial cells, and the consequences of gene-targeted mutation of individual isoforms are discussed in the context of the physiology of digestive organs. Where available, we also provide a review of pathophysiological states related to aberrant expression and/or activity of Na(+)/H(+) exchangers within the confines of the digestive system.

Apical NA+/H+ exchangers in the mammalian gastrointestinal tract. Publishing Authors By Initials

PR Kiela,H Xu,FK Ghishan,PR Kiela,H Xu,FK Ghishan,

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Apical NA+/H+ exchangers in the mammalian gastrointestinal tract. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of physiology and pharmacology : an offici

VOLUME: 57 Suppl 7

Page Numbers: 51-79

Journal Abbreviation: J. Physiol. Pharmacol.

ISSN: 0867-5910

DAY: 17

MONTH: Nov

YEAR: 2006

Apical NA+/H+ exchangers in the mammalian gastrointestinal tract. Information

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LANGUAGE: eng

NlmUniqueID: 9114501

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Grant and Affiliation Information for Apical NA+/H+ exchangers in the mammalian gastrointestinal tract.

AFFILIATION: Department of Pediatrics, Steele Children's Research Center, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA. pkiela@peds.arizona.edu

Country: Poland

AGENCY: United States NIDDK

GRANT: 5R01DK067286

ACRONYM: DK

MEDLINETA: J Physiol Pharmacol

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