Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits.

Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits. Research Abstract Details 

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Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits. Abstract Text:

Sandra L Pfister,

Hypercholesterolemia is considered a major risk factor in the development of atherosclerotic disease. The endothelium is the source of a number of vasoactive compounds which may be altered by the disease process. For example, synthesis of the arachidonic acid metabolite thromboxane A(2) (TXA(2)) increases in atherosclerosis. Non-selective blockade of vascular and platelet thromboxane (TP) receptors retards the progression of the disease in various animal models. We have previously identified a subset of NZW rabbits that lack only vascular (v) TP receptors, referred to as vTP-. These rabbits provide a unique model to elucidate the role of vascular TP receptors in hypercholesterolemia. Studies evaluated vascular responses to phenylephrine and acetylcholine in isolated aortic rings obtained from vTP- and vTP+ rabbits fed 0.5% cholesterol diet for a period of only 3 weeks. In the cholesterol-fed vTP- rabbits, contractions to phenylephrine were reduced compared to the vTP+ cholesterol-fed rabbits. Acetylcholine-induced relaxations were greater in cholesterol-fed vTP- rabbits compared to cholesterol-fed vTP+ rabbits. While the overall incidence of aortic lesions was small after only 3 weeks of cholesterol-feeding, results indicated a reduction in lesions in the vTP- compared to the vTP+ rabbits. In summary, these studies are the first to show that if rabbits lack only vascular TP receptors, impaired vascular reactivity responses normally associated with hypercholesterolemia are diminished.

Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits. Publishing Authors By Initials

SL Pfister,

For similar chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasodilator agents research abstracts see: chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasodilator agents research

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Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Atherosclerosis

VOLUME: 189

Page Numbers: 358-63

Journal Abbreviation: Atherosclerosis

ISSN: 0021-9150

DAY: 3

MONTH: 03

YEAR: 2006

Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 242543

Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits. Keywords Mesh Terms:

KEYWORDS: Vasodilator Agents

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits. Information

Substance Name: Cholesterol

Registry Number: 57-88-5

Grant and Affiliation Information for Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits.

AFFILIATION: Department of Pharmacology & Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. spfister@mcw.edu

Country: Ireland

AGENCY: United States NHLBI

GRANT: HL-57895

ACRONYM: HL

MEDLINETA: Atherosclerosis

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