Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease.

Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease. Research Abstract Details 

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Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease. Abstract Text:

Josepha Binder,Kent R Bailey,James B Seward,Ray W Squires,Takamu Kunihiro,Donald D Hensrud,Iftikhar J Kullo,

BACKGROUND: We investigated whether the aortic augmentation index (AIx), a measure of arterial wave reflection and stiffness, is associated with cardiorespiratory fitness in men without known coronary heart disease (CHD). METHODS: Asymptomatic men (n = 201, mean age 51 +/- 9.2 years) referred for a screening exercise electrocardiogram (ECG) underwent applanation tonometry to obtain radial artery pulse waveforms, and an ascending aortic pressure waveform was derived by a transfer function. The AIx is the difference between the first and second systolic peak of the ascending aortic pressure waveform, expressed as a percentage of the pulse pressure. Cardiorespiratory fitness was assessed by maximal oxygen consumption (VO2max mL/min/kg) during a symptom-limited graded exercise test. Multivariable regression analyses were used to identify significant independent determinants of AIx and of VO2 max. RESULTS: Diabetes was present in 2.5% of subjects, 34.8% had history of smoking, and 29% were hypertensive. Mean (+/- SD) AIx was 19.9% +/- 9.0% and mean VO(2 max) was 33.9 +/- 6.4 mL/min/kg. In a multivariable linear regression model, AIx was positively associated with age, hypertension, and history of smoking and inversely with heart rate, height, and body mass index (BMI). The VO2 max was significantly inversely related to AIx after adjustment for age, heart rate, height, and BMI (r = -0.22, P = .002), after further adjustment for CHD risk factors (total cholesterol, HDL-cholesterol, history of smoking, diabetes, hypertension) (P = .006), and after additional adjustment for behavioral factors (physical activity score, alcohol intake, and percent body fat) (P = .022). CONCLUSIONS: These findings indicate that AIx, a measure of arterial wave reflection and stiffness, is inversely associated with cardiorespiratory fitness in men without CHD.

Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease. Publishing Authors By Initials

J Binder,KR Bailey,JB Seward,RW Squires,T Kunihiro,DD Hensrud,IJ Kullo,

For similar circulatory and respiratory physiology: respiratory physiology research abstracts see: circulatory and respiratory physiology: respiratory physiology research

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Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of hypertension : journal of the

VOLUME: 19

Page Numbers: 1019-24

Journal Abbreviation: Am. J. Hypertens.

ISSN: 0895-7061

DAY: 3

MONTH: Oct

YEAR: 2006

Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease. Information

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LANGUAGE: eng

NlmUniqueID: 8803676

Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease. Keywords Mesh Terms:

KEYWORDS: Respiratory Physiology

MESH TERMS: physiology

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Grant and Affiliation Information for Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease.

AFFILIATION: Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

Country: United States

AGENCY: United States NCRR

GRANT: K23-RR17720

ACRONYM: RR

MEDLINETA: Am J Hypertens

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