Anxiety and regional cortical glucose metabolism in patients with Alzheimer's disease.

Anxiety and regional cortical glucose metabolism in patients with Alzheimer's disease. Research Abstract Details 

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Anxiety and regional cortical glucose metabolism in patients with Alzheimer's disease. Abstract Text:

Hiroshi Hashimoto,Lorena Monserratt,Peter Nguyen,Denise Feil,Dylan Harwood,Mark A Mandelkern,David L Sultzer,

In this study, the authors investigated the relationship between anxiety and regional cortical metabolism in Alzheimer's disease. Using the Neuropsychiatric Inventory (NPI), the authors evaluated anxiety in 41 patients with Alzheimer's disease. Regional cortical glucose metabolism was measured using [(18)F] fluorodeoxyglucose positron emission tomography in the resting state. Relationships were assessed using voxel-based (SPM2) and anatomic region-based analyses. Higher NPI anxiety score (frequency x severity) was associated with lower metabolism in bilateral entorhinal cortex, anterior parahippocampal gyrus, and left superior temporal gyrus and insula. Functional activity changes in distinct regions of the cortex contribute to the expression of anxiety in Alzheimer's disease.

Anxiety and regional cortical glucose metabolism in patients with Alzheimer's disease. Publishing Authors By Initials

H Hashimoto,L Monserratt,P Nguyen,D Feil,D Harwood,MA Mandelkern,DL Sultzer,

For similar behavioral disciplines and activities: psychiatric status rating scales research abstracts see: behavioral disciplines and activities: psychiatric status rating scales research

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MEDLINE DATE:

Anxiety and regional cortical glucose metabolism in patients with Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of neuropsychiatry and clinical neuros

VOLUME: 18

Page Numbers: 521-8

Journal Abbreviation:

ISSN: 0895-0172

DAY: 3

MONTH: 12

YEAR: 2006

Anxiety and regional cortical glucose metabolism in patients with Alzheimer's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8911344

Anxiety and regional cortical glucose metabolism in patients with Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Psychiatric Status Rating Scales

MESH TERMS: methods

Chemical & Substance for Abstract: Anxiety and regional cortical glucose metabolism in patients with Alzheimer's disease. Information

Substance Name: Fluorodeoxyglucose F18

Registry Number: 63503-12-8

Grant and Affiliation Information for Anxiety and regional cortical glucose metabolism in patients with Alzheimer's disease.

AFFILIATION: Department of Neuropsychiatry, Osaka City University Medical School, 1-4-3 Asahi-machi, abeno-ku, Osaka-city, Osaka 545-8585, Japan. hashimotoh@med.osaka-cu.ac.jp

Country: United States

AGENCY: United States NIMH

GRANT: MH56031

ACRONYM: MH

MEDLINETA: J Neuropsychiatry Clin Neurosc

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