Antiviral signaling through pattern recognition receptors.

Antiviral signaling through pattern recognition receptors. Research Abstract Details 

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Antiviral signaling through pattern recognition receptors. Abstract Text:

Taro Kawai,Shizuo Akira,

Viral infection is detected by the host innate immune system. Innate immune cells such as dendritic cells and macrophages detect nucleic acids derived from viruses through pattern recognition receptors (PRRs). Viral recognition by PRRs initiates the activation of signaling pathways that lead to production of type I interferon and inflammatory cytokines, which are important for the elimination of viruses. Two types of PRRs that recognize viral nucleic acids, Toll-like receptors (TLR) and RIG-I-like RNA helicases (RLH), have been identified. Of the TLRs, TLR3 recognizes viral double-stranded (ds) RNA, TLR7 and human TLR8 identify viral single-stranded (ss) RNA and TLR9 detects viral DNA. TLRs are located in endosomal compartments, whereas RLH are present in the cytoplasm where they detect viral dsRNA or ssRNA. Here we review the role of TLRs and RLHs in the antiviral innate immune response.

Antiviral signaling through pattern recognition receptors. Publishing Authors By Initials

T Kawai,S Akira,

For similar virus diseases research abstracts see: virus diseases research

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Antiviral signaling through pattern recognition receptors. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of biochemistry

VOLUME: 141

Page Numbers: 137-45

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 26

MONTH: 12

YEAR: 2006

Antiviral signaling through pattern recognition receptors. Information

Number of References: 69

LANGUAGE: eng

NlmUniqueID: 376600

Antiviral signaling through pattern recognition receptors. Keywords Mesh Terms:

KEYWORDS: Virus Diseases

MESH TERMS: metabolism

Chemical & Substance for Abstract: Antiviral signaling through pattern recognition receptors. Information

Substance Name: RNA Helicases

Registry Number: EC 2.7.7.-

Grant and Affiliation Information for Antiviral signaling through pattern recognition receptors.

AFFILIATION: Department of Host Defense, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

Country: Japan

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MEDLINETA: J Biochem

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