Antiviral prophylaxis and recurrence of hepatocellular carcinoma following liver transplantation in patients with hepatitis B.

Antiviral prophylaxis and recurrence of hepatocellular carcinoma following liver transplantation in patients with hepatitis B. Research Abstract Details 

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Antiviral prophylaxis and recurrence of hepatocellular carcinoma following liver transplantation in patients with hepatitis B. Abstract Text:

M A Zimmerman,R M Ghobrial,M J Tong,J R Hiatt,A M Cameron,R W Busuttil,M A Zimmerman,R M Ghobrial,M J Tong,J R Hiatt,A M Cameron,R W Busuttil,M A Zimmerman,R M Ghobrial,M J Tong,J R Hiatt,A M Cameron,R W Busuttil,

BACKGROUND: Orthotopic liver transplantation (OLT) is a viable treatment option for patients with hepatitis B (HBV) and concomitant hepatocellular carcinoma (HCC). However, cancer recurrence following transplantation approaches 20%. This study sought to identify the clinical and pathological factors associated with post-OLT survival. METHODS: Univariate and multivariate analyses considered the following variables: combination viral prophylaxis, HBV recurrence, tumor stage, vascular invasion, distribution, nodularity, pre- and post-OLT tumor size, pre-OLT alpha-fetoprotein (AFP), Milan and UCSF criteria, and Asian race. RESULTS: Cumulatively, HCC recurrence-free survival was 77%, 62%, and 53% at 1, 3, and 5 years, respectively, and was significantly better in patients who were free of viral recurrence post-OLT. Similarly, patients treated with combination prophylaxis had a significantly lower mortality than those who were not. CONCLUSIONS: Multivariate analysis revealed that AFP > 500 ng/mL, presence of vascular invasion by explant, HBV recurrence, and combination prophylaxis were independent predictors of HCC recurrence-free survival.

Antiviral prophylaxis and recurrence of hepatocellular carcinoma following liver transplantation in patients with hepatitis B. Publishing Authors By Initials

MA Zimmerman,RM Ghobrial,MJ Tong,JR Hiatt,AM Cameron,RW Busuttil,MA Zimmerman,RM Ghobrial,MJ Tong,JR Hiatt,AM Cameron,RW Busuttil,MA Zimmerman,RM Ghobrial,MJ Tong,JR Hiatt,AM Cameron,RW Busuttil,

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Antiviral prophylaxis and recurrence of hepatocellular carcinoma following liver transplantation in patients with hepatitis B. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Transplantation proceedings

VOLUME: 39

Page Numbers: 3276-80

Journal Abbreviation: Transplant. Proc.

ISSN: 0041-1345

DAY: 19

MONTH: Dec

YEAR: 2007

Antiviral prophylaxis and recurrence of hepatocellular carcinoma following liver transplantation in patients with hepatitis B. Information

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LANGUAGE: eng

NlmUniqueID: 243532

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AFFILIATION: Department of Surgery, Division of Liver and Pancreas Transplantation, The Pfleger Liver Institute, The Dumont-UCLA Transplant Center, The David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA.

Country: United States

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MEDLINETA: Transplant Proc

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