Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships.

Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships. Research Abstract Details 

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Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships. Abstract Text:

Tetsuji Hosono,Kazumi Yokomizo,Akiyuki Hamasaki,Yoshinari Okamoto,Tadashi Okawara,Masami Otsuka,Ryozaburo Mukai,Keitarou Suzuki,Tetsuji Hosono,Kazumi Yokomizo,Akiyuki Hamasaki,Yoshinari Okamoto,Tadashi Okawara,Masami Otsuka,Ryozaburo Mukai,Keitarou Suzuki,

The compound named Histidine-pyridine-histidine (HPH) is an oxygen-activating ligand derived from the structure of bleomycin. We synthesized HPH derivatives, namely HPH-1 to -8, and investigated their antiviral activities against herpes simplex virus type 1. HPH-8 showed potent antiviral activity with an EC50 of 15 microM, and relatively high cytotoxicity with a CC50 of 37 microM. In contrast, HPH-4 indicated a weaker antiviral activity with an EC50 of 79 microM, but exhibited a far more less cytotoxicity (CC50 500 microM). Other HPH derivatives showed no effects against antiviral activities and cytotoxicities.

Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships. Publishing Authors By Initials

T Hosono,K Yokomizo,A Hamasaki,Y Okamoto,T Okawara,M Otsuka,R Mukai,K Suzuki,T Hosono,K Yokomizo,A Hamasaki,Y Okamoto,T Okawara,M Otsuka,R Mukai,K Suzuki,

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Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 371-4

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 1464-3405

DAY: 24

MONTH: 10

YEAR: 2007

Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships.

AFFILIATION: Laboratory of Medicinal Microbiology, Yokohama College of Pharmacy, Kanagawa 245-0066, Japan. t.hosono@hamayaku.ac.jp

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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