Antitumour activity of cordycepin in mice.

Antitumour activity of cordycepin in mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Antitumour activity of cordycepin in mice. Abstract Text:

Noriko Yoshikawa,Kazuki Nakamura,Yu Yamaguchi,Satomi Kagota,Kazumasa Shinozuka,Masaru Kunitomo,Noriko Yoshikawa,Kazuki Nakamura,Yu Yamaguchi,Satomi Kagota,Kazumasa Shinozuka,Masaru Kunitomo,

SUMMARY 1. The antitumour effect of orally administered cordycepin, a component isolated from water extracts of Cordyceps sinensis, was examined in mice inoculated with B16 melanoma (B16-BL6) cells. 2. B16-BL6 (1 x 10(6)) cells were inoculated subcutaneously into the right footpad of mice. At 2 weeks after the cell inoculation, the enlarged primary tumour lump was weighed. Cordycepin (0, 5 and 15 mg/kg per day) was administered orally to the mice for 2 weeks from the date of tumour inoculation. Cordycepin (15 mg/kg per day) significantly reduced by 36% the wet weight of the primary tumour lump compared to that of the untreated control mice, without any loss of bodyweight or systemic toxicity. 3. Cordycepin (15 mg/kg per day) administered orally for 2 weeks inhibited the tumour enlargement in the right thigh inoculated with B16-BL6 cells premixed with extracellular matrix (Matrigel). 4. These results indicate that orally administered cordycepin inhibits melanoma cell growth in mice with no adverse effects.

Antitumour activity of cordycepin in mice. Publishing Authors By Initials

N Yoshikawa,K Nakamura,Y Yamaguchi,S Kagota,K Shinozuka,M Kunitomo,N Yoshikawa,K Nakamura,Y Yamaguchi,S Kagota,K Shinozuka,M Kunitomo,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Antitumour activity of cordycepin in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental pharmacology & physiolog

VOLUME: 31 Suppl 2

Page Numbers: S51-3

Journal Abbreviation: Clin. Exp. Pharmacol. Physiol.

ISSN: 0305-1870

DAY: 14

MONTH: Dec

YEAR: 2004

Antitumour activity of cordycepin in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 425076

Antitumour activity of cordycepin in mice. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Antitumour activity of cordycepin in mice. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Antitumour activity of cordycepin in mice.

AFFILIATION: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukpgawa Women's University, Nishinomiya, Japan.

Country: Australia

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Exp Pharmacol Physiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Antitumour activity of cordycepin in mice Related Publications

• Antitumour activity of cordycepin in mice.
• [Oxidative stress and atherosclerosis]