Antitumor and immunosuppressive activities of lankacidin-group antibiotics: structure-activity relationships.

Antitumor and immunosuppressive activities of lankacidin-group antibiotics: structure-activity relationships. Research Abstract Details 

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Antitumor and immunosuppressive activities of lankacidin-group antibiotics: structure-activity relationships. Abstract Text:

K Oostu,T Matsumoto,S Harada,T Kishi,

The antitumor and immunosuppressive activities of the lankacidin-group antibiotics were studied in mice. Seventeen of 29 newly prepared lankacidin-group antibiotics, including 14-derivatives of lankacidin C, lankacidinol, isolankacidinol, and lankacidinol 14-acetate, possessed considerable antitumor activity against ascites 6C3HED/OG lymphosarcoma. Comparative studies on the antitumor activity of lankacidin C and eight of its derivatives against L1210 leukemia and solid 6C3HED/OG lymphosarcoma demonstrated that replacement of the hydroxyl group at position 8 or 14 of lankacidin C by an acyloxy group potentiated antitumor activity. However, these modifications of lankacidin C resulted in reduction of the immunosuppressive activity.

Antitumor and immunosuppressive activities of lankacidin-group antibiotics: structure-activity relationships. Publishing Authors By Initials

K Oostu,T Matsumoto,S Harada,T Kishi,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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MEDLINE DATE: 1975 Sep-Oct

Antitumor and immunosuppressive activities of lankacidin-group antibiotics: structure-activity relationships. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer chemotherapy reports. Part 1

VOLUME: 59

Page Numbers: 919-28

Journal Abbreviation:

ISSN: 0069-0112

DAY: 20

MONTH: 02

YEAR: 2008

Antitumor and immunosuppressive activities of lankacidin-group antibiotics: structure-activity relationships. Information

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LANGUAGE: eng

NlmUniqueID: 7607105

Antitumor and immunosuppressive activities of lankacidin-group antibiotics: structure-activity relationships. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: transplantation

Chemical & Substance for Abstract: Antitumor and immunosuppressive activities of lankacidin-group antibiotics: structure-activity relationships. Information

Substance Name: Lactones

Registry Number: 0

Grant and Affiliation Information for Antitumor and immunosuppressive activities of lankacidin-group antibiotics: structure-activity relationships.

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Country: UNITED STATES

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MEDLINETA: Cancer Chemother Rep

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