Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)h NMR spectra.

Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)h NMR spectra. Research Abstract Details 

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Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)h NMR spectra. Abstract Text:

Yoshihide Usami,Yi-Nan Liu,An-Shen Lin,Makio Shibano,Toshiyuki Akiyama,Hideji Itokawa,Susan L Morris-Natschke,Kenneth Bastow,Ryoji Kasai,Kuo-Hsiung Lee,

Angiogenesis is a critical step in tumor progression and involves several steps including endothelial cell (EC) proliferation, migration, and matrix remodeling. We investigated the antiangiogenic effects of 20( S)-protopanaxadiol ( 1) and 20( S)-protopanaxatriol ( 2), the sapogenins of two major ginseng saponins, in an angiogenesis model of human umbilical vein endothelial cells (HUVECs). These compounds inhibited the proliferative activity of HUVECs in a dose-dependent manner and have potential as anticancer drug candidates. In addition, we report the complete and unambiguous assignment of (1)H NMR spectra of 1 and 2, based on analyses of 2D NMR spectra including COSY, NOESY, HSQC, and HMBC. This report is the first to completely assign the (1)H NMR signals of 2, together with correction of data for 1 from prior reports.

Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)h NMR spectra. Publishing Authors By Initials

Y Usami,YN Liu,AS Lin,M Shibano,T Akiyama,H Itokawa,SL Morris-Natschke,K Bastow,R Kasai,KH Lee,

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Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)h NMR spectra. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of natural products

VOLUME: 71

Page Numbers: 478-81

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ISSN: 0163-3864

DAY: 14

MONTH: 02

YEAR: 2008

Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)h NMR spectra. Information

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LANGUAGE: eng

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