Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.

Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. Research Abstract Details 

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Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. Abstract Text:

Linyi Wei,Qian Shi,Kenneth F Bastow,Arnold Brossi,Susan L Morris-Natschke,Kyoko Nakagawa-Goto,Tian-Shung Wu,Shiow-Lin Pan,Che-Ming Teng,Kuo-Hsiung Lee,

C9-Substituted phenanthrene-based tylophorine derivatives (PBTs) (13-36) were synthesized and evaluated as in vitro anticancer agents against the human A549 lung cancer cell line. Twelve active compounds were further examined against DU-145 (prostate), ZR-751 (breast), KB (nasopharyngeal), and KB-Vin (multidrug resistant KB subline) human cancer cell lines. They showed potent cytotoxic activity against both wild type and matched multidrug resistant KB cell lines, and displayed notable selectivity toward DU-145 (prostate) and ZR-751 (breast) cancer cell lines. The mode of action of this class may be distinctly different from that of other cancer chemotherapeutic compounds. Three PBT analogs were also evaluated in a murine model. Compound 24b showed modest in vivo antitumor activity against human A549 xenograft in nude mice as well as potent in vitro cytotoxic activity, and thus, is a promising anticancer lead compound.

Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. Publishing Authors By Initials

L Wei,Q Shi,KF Bastow,A Brossi,SL Morris-Natschke,K Nakagawa-Goto,TS Wu,SL Pan,CM Teng,KH Lee,

For similar surgical procedures, operative: transplantation: transplantation, heterologous research abstracts see: surgical procedures, operative: transplantation: transplantation, heterologous research

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Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of medicinal chemistry

VOLUME: 50

Page Numbers: 3674-80

Journal Abbreviation: J. Med. Chem.

ISSN: 0022-2623

DAY: 22

MONTH: 06

YEAR: 2007

Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9716531

Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. Keywords Mesh Terms:

KEYWORDS: Transplantation, Heterologous

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. Information

Substance Name: tylophorine

Registry Number: 482-20-2

Grant and Affiliation Information for Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents.

AFFILIATION: Natural Products Research Laboratories, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA17625

ACRONYM: CA

MEDLINETA: J Med Chem

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