Antisera to human renin normalize renin-dependent hypertension in the monkey: therapeutic implications.

Antisera to human renin normalize renin-dependent hypertension in the monkey: therapeutic implications. Research Abstract Details 

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Antisera to human renin normalize renin-dependent hypertension in the monkey: therapeutic implications. Abstract Text:

E E Slater,P Corvol,J Menard,J Burton,L H Hartley,

Polyclonal antisera raised against pure human renin normalize renin-dependent blood pressure elevation in the monkey (M. fascicularis). In vitro, comparable inhibition of either human or monkey plasma renin by the antisera was demonstrated. In vivo, intravenous infusion of 2 ml of antisera did not change mean arterial pressure of salt-repleted monkeys, however, its administration to salt-depleted monkeys with elevated plasma renin activity lowered mean arterial pressure 10 Torr. A 25 Torr rise in mean arterial pressure and increase in plasma renin activity occurred promptly after inflation of a suprarenal aortic cuff in conscious uninephrectomized monkeys. Administration of 2 ml of antisera to these monkeys normalized mean pressure, which was reduced by an additional 10 Torr if the animals were previously salt-depleted. Maximal hypotension occurred within 1 hour and was sustained for approximately 10 hours. Because of the differing specificities of polyclonal antisera, sera raised in two laboratories against human renin purified from different sources were employed. Identical results were obtained. This is the first demonstration of the use of antisera to inhibit endogenous renin activity in primates and predicts the in vivo efficacy of renin antisera as experimental, diagnostic and therapeutic agents.

Antisera to human renin normalize renin-dependent hypertension in the monkey: therapeutic implications. Publishing Authors By Initials

EE Slater,P Corvol,J Menard,J Burton,LH Hartley,

For similar peptides: oligopeptides: teprotide research abstracts see: peptides: oligopeptides: teprotide research

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Antisera to human renin normalize renin-dependent hypertension in the monkey: therapeutic implications. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 6

Page Numbers: 923-37

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1984

Antisera to human renin normalize renin-dependent hypertension in the monkey: therapeutic implications. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

Antisera to human renin normalize renin-dependent hypertension in the monkey: therapeutic implications. Keywords Mesh Terms:

KEYWORDS: Teprotide

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Antisera to human renin normalize renin-dependent hypertension in the monkey: therapeutic implications. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Antisera to human renin normalize renin-dependent hypertension in the monkey: therapeutic implications.

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Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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