Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest.

Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest. Research Abstract Details 

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Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest. Abstract Text:

Brent J Yoder,Shugeng Cao,Andrew Norris,James S Miller,Fidy Ratovoson,Jeremi Razafitsalama,Rabodo Andriantsiferana,Vincent E Rasamison,David G I Kingston,

Bioassay-guided fractionation of an extract of the fruit of Macaranga alnifolia from Madagascar led to the isolation of four new prenylated stilbenes, schweinfurthins E-H (1-4), and one new geranylated dihydroflavonol, alnifoliol (5). The known prenylated stilbene vedelianin (6) and the known geranylated flavonoids bonanniol A (7), diplacol (8), bonannione A (9), and diplacone (10) were also isolated. All 10 compounds were tested for antiproliferative activity in the A2780 human ovarian cancer cell line assay. Vedelianin (IC50 = 0.13 microM) exhibited the greatest activity among all isolates, while schweinfurthin E (IC50 = 0.26 microM) was the most potent of the new compounds.

Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest. Publishing Authors By Initials

BJ Yoder,S Cao,A Norris,JS Miller,F Ratovoson,J Razafitsalama,R Andriantsiferana,VE Rasamison,DG Kingston,

For similar cells: cells, cultured: tumor cells, cultured research abstracts see: cells: cells, cultured: tumor cells, cultured research

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Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of natural products

VOLUME: 70

Page Numbers: 342-6

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 28

MONTH: 02

YEAR: 2007

Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest. Information

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LANGUAGE: eng

NlmUniqueID: 7906882

Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest. Keywords Mesh Terms:

KEYWORDS: Tumor Cells, Cultured

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest. Information

Substance Name: Stilbenes

Registry Number: 0

Grant and Affiliation Information for Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest.

AFFILIATION: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

Country: United States

AGENCY: United States FIC

GRANT: TW 000313

ACRONYM: TW

MEDLINETA: J Nat Prod

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