Antiproliferative Limonoids of a Malleastrum sp. from the Madagascar Rainforest(,).

Antiproliferative Limonoids of a Malleastrum sp. from the Madagascar Rainforest(,). Research Abstract Details 

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Antiproliferative Limonoids of a Malleastrum sp. from the Madagascar Rainforest(,). Abstract Text:

Brian T Murphy,Peggie Brodie,Carla Slebodnick,James S Miller,Chris Birkinshaw,Lucien M Randrianjanaka,Rabodo Andriantsiferana,Vincent E Rasamison,Karen Tendyke,Edward M Suh,David G I Kingston,

Bioassay-guided fractionation of an ethanol extract of a Malleastrum sp. afforded three new limonoids, malleastrones A-C ( 1- 3), respectively. Each limonoid contained a rare tetranortriterpenoid skeleton. Structure elucidation of the isolates was carried out by analysis of one- and two-dimensional NMR and X-ray diffraction data. The novel isolates 1 and 2 were tested for antiproliferative activity against a panel of cancer cell lines and exhibited IC 50 values ranging from 0.19 to 0.63 microM.

Antiproliferative Limonoids of a Malleastrum sp. from the Madagascar Rainforest(,). Publishing Authors By Initials

BT Murphy,P Brodie,C Slebodnick,JS Miller,C Birkinshaw,LM Randrianjanaka,R Andriantsiferana,VE Rasamison,K Tendyke,EM Suh,DG Kingston,

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Antiproliferative Limonoids of a Malleastrum sp. from the Madagascar Rainforest(,). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of natural products

VOLUME: 71

Page Numbers: 325-9

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ISSN: 0163-3864

DAY: 5

MONTH: 01

YEAR: 2008

Antiproliferative Limonoids of a Malleastrum sp. from the Madagascar Rainforest(,). Information

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LANGUAGE: eng

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